Evidence map›Paper›PMID 30969507›Full record

ArticleThe New England journal of medicine2019

Treatment of Progressive Multifocal Leukoencephalopathy with Pembrolizumab.

Sebastian Rauer, Reinhard Marks, Horst Urbach, Klaus Warnatz, Avindra Nath, Steve Holland, Cornelius Weiller, Bodo Grimbacher

Abstract readCase ReportsLetter
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Adoptive T-cell therapy for virus-associated diseases.Clinical microbiology reviews · 2025
    Review
  2. Ten Years ofNeurology(R) neuroimmunology & neuroinflammation · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Single-Dose Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy.Neurology(R) neuroimmunology & neuroinflammation · 2021
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sebastian RauerAlbert Ludwigs University, Freiburg, Germany sebastian.rauer@uniklinik-freiburg.de.
Reinhard MarksAlbert Ludwigs University, Freiburg, Germany sebastian.rauer@uniklinik-freiburg.de.
Horst UrbachAlbert Ludwigs University, Freiburg, Germany sebastian.rauer@uniklinik-freiburg.de.
Klaus WarnatzAlbert Ludwigs University, Freiburg, Germany sebastian.rauer@uniklinik-freiburg.de.
Avindra NathNational Institutes of Health, Bethesda, MD.
Steve HollandNational Institutes of Health, Bethesda, MD.
Cornelius WeillerAlbert Ludwigs University, Freiburg, Germany.
Bodo GrimbacherAlbert Ludwigs University, Freiburg, Germany.

Funding

Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, Monoclonal, HumanizedBrainCD8-Positive T-LymphocytesCerebrospinal FluidHumansImmunologic FactorsJC VirusLeukoencephalopathy, Progressive MultifocalMagnetic Resonance ImagingMaleProgrammed Cell Death 1 ReceptorViral LoadWhite MatterAntibodies, Monoclonal, HumanizedImmunologic FactorsPDCD1 protein, humanpembrolizumabProgrammed Cell Death 1 Receptor

Identifiers

PMID30969507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.