Evidence map›Paper›PMID 30969502›Full record

ArticleThe New England journal of medicine2019

Can Immune Checkpoint Inhibitors Keep JC Virus in Check?

Igor J Koralnik

Abstract readEditorialComment
In one paragraph

Article in The New England journal of medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Vitamin D can reduce severity in COVID-19 through regulation of PD-L1.Naunyn-Schmiedeberg's archives of pharmacology · 2022
    Review
  4. Article
  5. Potential protective role of the anti-PD-1 blockade against SARS-CoV-2 infection.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Review
  6. T cell immunobiology and cytokine storm of COVID-19.Scandinavian journal of immunology · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Progressive multifocal leukoencephalopathy after CAR T therapy.International journal of hematology · 2020
    Article
  12. Review
  13. American journal of respiratory cell and molecular biology · 2020
    Article
  14. Article
  15. Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
  16. Pembrolizumab as a treatment for PML? Waiting for Godot.Neurology(R) neuroimmunology & neuroinflammation · 2019
    Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Igor J KoralnikFrom the Department of Neurological Sciences, Rush University Medical Center, Chicago.

Funding

Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
NINDS NIH HHS R01 NS047029
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukoencephalopathy, Progressive MultifocalAntibodies, Monoclonal, HumanizedHumansJC VirusNatalizumabAntibodies, Monoclonal, HumanizedNatalizumabpembrolizumab

Identifiers

PMID30969502
PMCPMC8656172

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.