Evidence map›Paper›PMID 30969408›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

Assessment of Conformational State Transitions of Class B GPCRs Using Molecular Dynamics.

Chenyi Liao, Victor May, Jianing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chenyi LiaoDepartment of Chemistry, The University of Vermont, Burlington, VT, USA.
Victor MayDepartment of Neurological Sciences, Larner College of Medicine, The University of Vermont, Burlington, VT, USA.
Jianing LiDepartment of Chemistry, The University of Vermont, Burlington, VT, USA. jianing.li@uvm.edu.
University of Vermont · US

Funding

TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3M
Structure, Mechanism, and Regulation of PACAP/VIP GPCR SubtypesR01GM129431 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LI, JIANING · 2018 to 2022
$1.7M
NIGMS NIH HHS P41 GM103712NIGMS NIH HHS R01 GM129431
6 · The paper itself

Abstract

Class B G protein-coupled receptors (GPCRs) comprise a family of 15 peptide-binding members, which are crucial targets for endocrine, metabolic, and stress-related disorders. While their protein structures and dynamics remain largely unclear, computer modeling and simulations represent a promising means to help solve such puzzles. Herein, we present a basic introduction to the methodology of molecular dynamics (MD) simulations and two analytical methods to assess the conformational ensembles and transitions of Class B GPCRs, using our recent studies of the human pituitary adenylate cyclase activating polypeptide (PAC

Indexed as

Molecular Dynamics SimulationProtein ConformationHumansKineticsLigandsMarkov ChainsModels, MolecularProtein BindingReceptors, G-Protein-CoupledLigandsReceptors, G-Protein-CoupledCommunication networksConformational ensembleMarkov state modelMolecular dynamicsMultiscale modeling

Identifiers

PMID30969408
PMCPMC6571028
OpenAlexW2937469079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.