ArticleeLife2019
State-dependent geometry of population activity in rat auditory cortex.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Visual field map size constrains working memory precision.bioRxiv : the preprint server for biology · 2026Article
- Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Sharp Waves, Bursts, and Coherence: Activity in a Songbird Vocal Circuit Is Influenced by Behavioral State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Efficient and reliable spike sorting from neural recordings with UMAP-based unsupervised nonlinear dimensionality reduction.PLoS biology · 2025Article
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Linking neural population formatting to function.bioRxiv : the preprint server for biology · 2025Article
- Alterations in topology, cost, and dynamics of gamma-band EEG functional networks in a preclinical model of traumatic brain injury.Network neuroscience (Cambridge, Mass.) · 2025Article
- Auditory cortex conveys non-topographic sound localization signals to visual cortex.Nature communications · 2024Article
- All-optical recreation of naturalistic neural activity with a multifunctional transgenic reporter mouse.Cell reports · 2023Article
- Geometry of population activity in spiking networks with low-rank structure.PLoS computational biology · 2023Article
- Response outcome gates the effect of spontaneous cortical state fluctuations on perceptual decisions.eLife · 2023Article
- Aligning latent representations of neural activity.Nature biomedical engineering · 2023Article
- Hierarchical unimodal processing within the primary somatosensory cortex during a bimodal detection task.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- An abstract categorical decision code in dorsal premotor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neural population geometry: An approach for understanding biological and artificial neural networks.Current opinion in neurobiology · 2021Review
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Authors and funding
5 authors.
Funding
Abstract
The accuracy of the neural code depends on the relative embedding of signal and noise in the activity of neural populations. Despite a wealth of theoretical work on population codes, there are few empirical characterizations of the high-dimensional signal and noise subspaces. We studied the geometry of population codes in the rat auditory cortex across brain states along the activation-inactivation continuum, using sounds varying in difference and mean level across the ears. As the cortex becomes more activated, single-hemisphere populations go from preferring contralateral loud sounds to a symmetric preference across lateralizations and intensities, gain-modulation effectively disappears, and the signal and noise subspaces become approximately orthogonal to each other and to the direction corresponding to global activity modulations. Level-invariant decoding of sound lateralization also becomes possible in the active state. Our results provide an empirical foundation for the geometry and state-dependence of cortical population codes.
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