Evidence map›Paper›PMID 30969098›Full record

ArticleACS applied materials & interfaces2019

Assessment of Targeted Nanoparticle Assemblies for Atherosclerosis Imaging with Positron Emission Tomography and Potential for Clinical Translation.

Yongjian Liu, Hannah P Luehmann, Lisa Detering, Eric D Pressly, Alaina J McGrath, Deborah Sultan, Annie Nguyen, Susannah Grathwohl, Monica Shokeen, Mohamed Zayed and 4 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  3. Review
  4. Review
  5. Immunomodulation in age-related disorders and nanotechnology interventions.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023
    Review
  6. Review
  7. Review
  8. Nanotechnology for cardiovascular diseases.Innovation (Cambridge (Mass.)) · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Hannah P Luehmann
Lisa Detering
Eric D PresslyMaterials Department , University of California , Santa Barbara , California 93106 , United States.
Alaina J McGrathMaterials Department , University of California , Santa Barbara , California 93106 , United States.
Deborah Sultan
Annie Nguyen
Susannah Grathwohl
Monica Shokeen
Mohamed Zayed
Robert J Gropler
Dana Abendschein
Craig J HawkerMaterials Department , University of California , Santa Barbara , California 93106 , United States.ORCID http://orcid.org/0000-0001-9951-851X
Pamela K Woodard
Mallinckrodt (United States) · USWashington University in St. Louis · USUniversity of California, Santa Barbara · US

Funding

THE ROLE OF PHOSPHOLIPOGENESIS IN DIABETIC PERIPHERAL ARTERIAL DISEASEK08HL132060 · NHLBI · WASHINGTON UNIVERSITY · PI ZAYED, MOHAMED A. · 2017 to 2021
$466k
NHLBI NIH HHS HHSN268201000046CNHLBI NIH HHS K08 HL132060
6 · The paper itself

Abstract

Nanoparticles have been assessed in preclinical models of atherosclerosis for detection of plaque complexity and treatment. However, their successful clinical translation has been hampered by less than satisfactory plaque detection and lack of a general strategy for assessing the translational potential of nanoparticles. Herein, nanoparticles based on comb-co-polymer assemblies were synthesized through a modular construction approach with precise control over the conjugation of multiple functional building blocks for in vivo evaluation. This high level of design control also allows physicochemical properties to be varied in a controllable fashion. Through conjugation of c-atrial natriuretic factor (CANF) peptide and radiolabeling with

Indexed as

Positron-Emission TomographyAnimalsAtherosclerosisAtrial Natriuretic FactorCopper RadioisotopesDisease Models, AnimalFemoral ArteryHumansNanoparticlesPlaque, AtheroscleroticRabbitsRadiopharmaceuticalsReceptors, Atrial Natriuretic FactorAtrial Natriuretic Factoratrial natriuretic factor receptor CCopper-64Copper RadioisotopesRadiopharmaceuticalsReceptors, Atrial Natriuretic FactoratherosclerosisnanoparticleNPRCpositron emission tomographytranslation

Identifiers

PMID30969098
PMCPMC6918720
OpenAlexW2935780035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.