Evidence map›Paper›PMID 30968993›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

Repeatability of regional pulmonary functional metrics of Hyperpolarized

Andrew D Hahn, Jeff Kammerman, Michael Evans, Wei Zha, Robert V Cadman, Keith Meyer, Nathan Sandbo, Sean B Fain

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Combining hyperpolarizedJournal of applied physiology (Bethesda, Md. : 1985) · 2025
    Article
  5. Article
  6. Article
  7. Quantifying Regional Radiation-Induced Lung Injury in Patients Using HyperpolarizedInternational journal of radiation oncology, biology, physics · 2024
    Article
  8. Initial feasibility and challenges of hyperpolarizedMagnetic resonance in medicine · 2023
    Article
  9. Establishing a hemoglobin adjustment forMagnetic resonance in medicine · 2023
    Article
  10. Lung Volume Dependence and Repeatability of HyperpolarizedRadiology. Cardiothoracic imaging · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. HyperpolarizedRadiology · 2022
    Article
  15. PediatricJournal of magnetic resonance imaging : JMRI · 2022
    Article
  16. Article
  17. Article
  18. HyperpolarizedInternational journal of radiation oncology, biology, physics · 2021
    Article
  19. HyperpolarizedRadiology · 2021
    Article
  20. Regional Gas Exchange Measured byJournal of magnetic resonance imaging : JMRI · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrew D HahnDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.
Jeff KammermanDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.
Michael EvansDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, USA.
Wei ZhaDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0002-6914-8092
Robert V CadmanDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.
Keith MeyerDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Nathan SandboDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Sean B FainDepartment of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0001-5461-0646
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung DiseaseS10OD016394 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI FAIN, SEAN BEDILION · 2013 to 2013
$600k
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NHLBI NIH HHS R01 HL126771NIH HHS S10 OD016394
6 · The paper itself

Abstract

backgroundMRI of hyperpolarized PURPOSE: To quantify global average and regional repeatability of Barrier:gas, RBC:gas, and RBC:Barrier ratios derived from dissolved-phase STUDY TYPE: Prospective. POPULATION: Fourteen healthy volunteers. One subject was unable to complete the study resulting in 13 subjects for analysis (eight female, five male, ages 24-69, 53.8 ± 13.9). FIELD STRENGTH: 1.5T. ASSESSMENT: Subjects were imaged using a 3D radial 1-point Dixon method to separate Barrier and RBC component signals, at two different timepoints, with ~1 month between visits. RBC:Gas, Barrier:Gas, and RBC:Barrier measures were compared across time and with pulmonary function tests (PFTs). STATISTICAL TESTS: Repeatablilty was quantified using Bland-Altman plots, coefficient of repeatability, coefficient of variation (CV), and intraclass correlation coefficients (ICCs). Dependence of imaging measures on PFTs and lung volume was evaluated using Spearman and Pearson correlation coefficients, respectively. Statistical significance was determined by F-test for intraclass correlations, and t-test for Spearman correlations and regression.

resultsMean RBC:Gas, Barrier:Gas, and RBC:Barrier had CVs of 19.2%, 20.0%, and 11.5%, respectively, and had significant ICCs, equal to 0.78, 0.79, and 0.92, respectively. Intervisit differences in RBC:Barrier were significantly correlated with intervisit differences in DL DATA

conclusionThree commonly used LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:1182-1190.

Indexed as

Xenon IsotopesAdultAgedFemaleHumansLungMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesReference ValuesReproducibility of ResultsRespiratory Function TestsYoung AdultXenon Isotopes

Identifiers

PMID30968993
PMCPMC6750965
OpenAlexW2937481901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.