Evidence map›Paper›PMID 30968883›Full record

ArticleThe Analyst2019

Lateral flow assay ruler for quantitative and rapid point-of-care testing.

Zhao Li, Hui Chen, Ping Wang

Open access · greenAbstract read
In one paragraph

Article in The Analyst, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhao LiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA. Ping.Wang2@uphs.upenn.edu.ORCID http://orcid.org/0000-0002-9648-9618
Hui ChenDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA. Ping.Wang2@uphs.upenn.edu.ORCID http://orcid.org/0000-0002-9422-8959
Ping WangDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA. Ping.Wang2@uphs.upenn.edu.
California University of Pennsylvania · US

Funding

Development of a Point-of-Care Volumetric Bar-Chart Chip for Drug QuantitationR01DA035868 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI QIN, LIDONG, WANG, PING · 2013 to 2020
$4.3M
NIDA NIH HHS R01 DA035868
6 · The paper itself

Abstract

Lateral flow assay (LFA) is a well-established platform for point-of-care (POC) testing due to its low cost and user friendliness. Conventional LFAs provide qualitative or semi-quantitative results and require dedicated instruments for quantitative detection. Here, we developed an "LFA ruler" for quantitative and rapid readout of LFA results, using a 3D printed strip cassette and a simple, inexpensive microfluidic chip. Platinum nanoparticles are used as signal amplification reporters, which catalyze the generation of oxygen to push ink advancement in the microfluidic channel. The concentration of the target is linearly correlated with the ink advancement distance. The entire assay can be completed within 30 minutes without external instruments and complicated operations. We demonstrated quantitative prostate specific antigen testing using the LFA ruler, with a limit of detection of 0.54 ng mL

Indexed as

Lab-On-A-Chip DevicesEquipment DesignHumansHydrogen PeroxideLimit of DetectionMaleMetal NanoparticlesMicrofluidic Analytical TechniquesOxidation-ReductionOxygenPlatinumPoint-of-Care TestingPrinting, Three-DimensionalProstate-Specific AntigenHydrogen PeroxideOxygenPlatinumProstate-Specific Antigen

Identifiers

PMID30968883
PMCPMC7169999
OpenAlexW2924669022

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.