Evidence map›Paper›PMID 30968825›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2019

The seroprevalence of untreated chronic hepatitis C virus (HCV) infection and associated risk factors in male Irish prisoners: a cross-sectional study, 2017.

Desmond Crowley, John S Lambert, Graham Betts-Symonds, Walter Cullen, Mary Keevans, Enda Kelly, Eamon Laird, Tina McHugh, Susan McKiernan, Sarah Jayne Miggin and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  5. Retrospective review of rates of sexually transmitted and blood-borne infection (STBBI) testing in provincial corrections facilities in Newfoundland and Labrador.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Desmond CrowleyIrish College of General Practitioners, Dublin, Ireland.
John S LambertSchool of Medicine, University College Dublin, Dublin, Ireland.
Graham Betts-SymondsIrish Red Cross, Dublin, Ireland.
Walter CullenSchool of Medicine, University College Dublin, Dublin, Ireland.
Mary KeevansIrish Prison Service, Dublin, Ireland.
Enda KellyIrish Prison Service, Dublin, Ireland.
Eamon LairdTrinity College Dublin, Dublin, Ireland.
Tina McHughMater Misericordiae University Hospital, Dublin, Ireland.
Susan McKiernanSt. James' Hospital, Dublin, Ireland.
Sarah Jayne MigginSt. James' Hospital, Dublin, Ireland.
Carol MurphyIrish Prison Service, Dublin, Ireland.
Ross MurtaghSchool of Medicine, University College Dublin, Dublin, Ireland.
Deirdre O'ReillyIrish Prison Service, Dublin, Ireland.
Ciara TobinUniversity of Florida, Gainesville, United States.
Marie Claire Van HoutLiverpool John Moores University, Liverpool, United Kingdom.
University College Dublin · IESt. James's Hospital · IEIrish Hospice Foundation · IELiverpool John Moores University · GBMater Misericordiae University Hospital · IETrinity College Dublin · IEUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionData on chronic hepatitis C (HCV) infection prevalence in European prisons are incomplete and impact the public health opportunity that incarceration provides.AimsWe aimed to estimate the seroprevalence of untreated chronic HCV infection and to identify associated risk factors in an Irish male prison.MethodsWe conducted a cross-sectional study involving a researcher-administered questionnaire, review of medical records and HCV serology.ResultsOf 422 prisoners (78.0% of the study population) who participated in the study, 298 (70.6%) completed the questionnaire and 403 (95.5%) were tested for HCV antibodies. Of those tested, 92 (22.8%) were HCV antibody-positive, and of those, 53 (57.6%) were HCV RNA-positive, 23 (25.0%) had spontaneous clearance, 16 (17.4%) had a sustained viral response, 10 (11.0%) were co-infected with HIV and six (6.0%) with HBV. The untreated chronic HCV seroprevalence estimate was 13.1% and the seroprevalence of HCV among prisoners with a history of injecting drug use (IDU) was 79.7%. Risk factors significantly associated with past HCV infection were IDU (p < 0.0001), having received a prison tattoo (p < 0.0001) or a non-sterile community tattoo (p < 0.0001), sharing needles and other drug-taking paraphernalia (p < 0.0001). Small numbers of prisoners had a history of sharing razors (n=10; 3.4%) and toothbrushes (n=3; 1.0%) while incarcerated. On multivariable analysis, history of receiving a non-sterile community tattoo was the only significant risk factor associated with HCV acquisition (after IDU was removed from the model) (p = 0.005, β = 0.468).ConclusionThe level of untreated chronic HCV infection in Irish prisons is high, with IDU the main associated risk.

Indexed as

PrisonsAdultCross-Sectional StudiesDrug UsersHepacivirusHepatitis CHepatitis C AntibodiesHepatitis C, ChronicHumansIrelandMaleMiddle AgedPrevalencePrisonersReal-Time Polymerase Chain ReactionRisk FactorsHepatitis C AntibodiesRNA, Viralblood-borne infectionsdrug usersepidemiologyhepatitis Chepatitis C virusinjecting HCVIrelandprevalenceprisonerspublic health policyrisksviral infections

Identifiers

PMID30968825
PMCPMC6462789
OpenAlexW2925821350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.