ArticleMolecular genetics & genomic medicine2019
Achillea biebersteinni Afan may inhibit scar formation: In vitro study.
Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
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- Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing.International journal of molecular sciences · 2024Review
- Distribution of Phenolic Compounds and Antioxidant Activity in Plant Parts and Populations of Seven Underutilized WildPlants (Basel, Switzerland) · 2022Article
- Exosomal ncRNAs: The pivotal players in diabetic wound healing.Frontiers in immunology · 2022Review
- Identification of Mushroom and Murine Tyrosinase Inhibitors fromMolecules (Basel, Switzerland) · 2021Article
- Review
- Article
- [Experimental study of human amniotic mesenchymal stem cell exosome promoting fibroblasts migration through microRNA-135a].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Article
- Effects of Hydroxytyrosol on Expression of Apoptotic Genes and Activity of Antioxidant Enzymes in LS180 Cells.Cancer management and research · 2020Article
- Achillea biebersteinni Afan may inhibit scar formation: In vitro study.Molecular genetics & genomic medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOne of the major problems in wound healing is scar formation; however, there are few ways to prevent or treat it. Different species of Achillea are used to treat wounds in folk medicine from the past but there are few studies on the effect of it on wound healing and inhibition of scar formation. The aim of this study was to investigate the effect of Achillea biebersteinii Afan hydroethanolic extract on the expression of TGFβ1 and bFGF as effective growth factors of wound healing in mouse embryonic fibroblast cells.
methodsMouse embryonic fibroblast cells were exposed to different concentrations of Achillea extract at two different time (12 and 24 hr); the expression of TGFβ1 and bFGF was performed by real-time-PCR and ELISA at the level of gene and protein.
resultsIt was observed that the plant extract at 5 and 10 µg/ml downregulated the expression of TGFβ1 and upregulated the expression of bFGF at the level of gene and protein.
conclusionThe results showed that the pattern of changes in the expression of TGFβ1 and bFGF by Achillea biebersteinni Afan extract may inhibit scar formation.
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