ArticleCancer medicine2019
Acute kidney injury predicts all-cause mortality in patients with cancer.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Incidence and risk factors of acute kidney injury in patients with malignant tumors: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- Acute kidney injury during treatment of pediatric brain tumors: a retrospective analysis of survivors.Pediatric research · 2026Article
- Efficacy of Prophylactic Magnesium Therapy for the Prevention of Cisplatin-Induced Renal Injury: A Meta-Analysis.Journal of clinical medicine · 2026Review
- Clinical characteristics and outcomes of critically ill women with gynecologic malignancies: a two-database retrospective study using MIMIC-IV v3.1 and eICU-CRD v2.0.BMC women's health · 2026Article
- Cardiovascular and Renal Risk Stratification in Patients Referred to an Onconephrology Clinic and Undergoing Different Oncology Therapies: A Real-World Study.Biomedicines · 2026Article
- Kidney Biopsy in Cancer Patients With Acute Kidney Disease: Histological Findings and Kidney Outcomes.Cureus · 2026Article
- Trends in mortality among patients with malignant neoplasm of kidney in the United States, 1999-2023: a retrospective study.BMC cancer · 2026Article
- Mortality trends of malignant neoplasm of kidney among 5-85+ year-olds in the United States: a retrospective analysis.Frontiers in oncology · 2026Article
- Knowledge mapping and visualized analysis of research progress in onconephrology: a bibliometric analysis.Renal failure · 2025Article
- External validation and comparison of clinical prediction models for cisplatin-associated acute kidney injury: a single-centre retrospective study.Journal of pharmaceutical health care and sciences · 2025Article
- Acute kidney injury: pathogenesis and therapeutic interventions.Molecular biomedicine · 2025Review
- Observational
- Global burden of anticancer drug-induced acute kidney injury and tubulointerstitial nephritis from 1967 to 2023.Scientific reports · 2024Article
- Chapter 1: Evaluation of kidney function in patients undergoing anticancer drug therapy, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022.International journal of clinical oncology · 2023Review
- Do outcomes for patients with hospital-acquired Acute Kidney Injury (H-AKI) vary across specialties in England?BMC nephrology · 2023Observational
- Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltrates.Oncoimmunology · 2022Article
- Management of acute kidney injury in gastrointestinal tumor: An overview.World journal of clinical cases · 2021Review
- Clinical Significance of Acute Kidney Injury in Lung Cancer Patients.Cancer research and treatment · 2021Article
- Prognostic Implications of a Cumulative Renal Score Based on Both Serum Creatinine and Urine Output Criteria for Staging of Acute Kidney Injury: A Cohort Study.International journal of general medicine · 2021Article
- Acute kidney injury predicts all-cause mortality in patients with cancer.Cancer medicine · 2019Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is a critical issue in cancer patients because it is not only a morbid complication but also able to interrupt timely diagnostic evaluation or planned optimal treatment. However, the impact of AKI on overall mortality in cancer patients remains unclear.
methodsWe conducted a retrospective cohort study of 67 986 cancer patients, from 2004 to 2013 to evaluate the relationship between AKI and all-cause mortality. We used KDIGO AKI definition and grading system.
resultsDuring 3.9 ± 3.1 years of follow-up, 33.8% of the patients experienced AKI at least once. Among AKI events, stage 1, 2, and 3 was 71.0%, 13.8%, and 15.1%, respectively. AKI incidence was highest in hematologic malignancies, followed by urinary tract cancer, and hepatocellular carcinoma. Male sex, older age, underlying diabetes and hypertension, lower serum albumin and plasma hemoglobin, more frequent radio-contrast exposure, entrance of clinical trials, and receiving chemotherapy were associated with AKI occurrence. AKI development was an independent risk factor for elevated mortality in cancer patients with dose-responsive manner (Stage 1, hazard ratio [HR] 1.183, 95% confidence interval [CI] 1.145-1.221, P < 0.001; Stage 2, HR 1.710, 95% CI 1.629-1.796; Stage 3, HR 2.000, 95% CI 1.910-2.095; No AKI, reference group) even after adjustment. This tendency was reproduced in various cancer types except thyroid cancer and in various treatment modalities, however, not shown in patients with baseline renal dysfunction.
conclusionAKI was an independent risk factor for all-cause mortality in overall cancer patients with dose-responsive manner.
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