ArticleCNS neuroscience & therapeutics2020
Development and validation of a new score for predicting functional outcome of neurocritically ill patients: The INCNS score.
Article in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Low-Dose Buprenorphine Initiations During Opioid and Sedative Weaning in Mechanically Ventilated Neurocritical Care Patients: A Retrospective Pilot Cohort Study.Neurocritical care · 2026Article
- Evaluation and comparison of mortality scores in status epilepticus patients.BMC neurology · 2025Article
- A combined superiority and non-inferiority procedure for comparing predictive values of two diagnostic tests.Journal of applied statistics · 2024Article
- Severity scores for status epilepticus in the ICU: systemic illness also matters.Critical care (London, England) · 2023Observational
- C-reactive protein-albumin ratio and procalcitonin in predicting intensive care unit mortality in traumatic brain injury.Acute and critical care · 2022Article
- Ethical and social implications of approaching death prediction in humans - when the biology of ageing meets existential issues.BMC medical ethics · 2020Article
- Development and validation of a new score for predicting functional outcome of neurocritically ill patients: The INCNS score.CNS neuroscience & therapeutics · 2020Article
- A Novel INCNS Score for Prediction of Mortality and Functional Outcome of Comatose Patients.Frontiers in neurology · 2020Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo develop and validate a novel score for prediction of 3-month functional outcome in neurocritically ill patients.
methodsThe development of the novel score was based on two widely used scores for general critical illnesses (Acute Physiology and Chronic Health Evaluation II, APACHE II; Simplified Acute Physiology Score II, SAPS II) and consideration of the characteristics of neurocritical illness. Data from consecutive patients admitted to neurological ICU (N-ICU) between January 2013 and June 2016 were used for the validation. The modified Rankin Scale (mRS) was used to evaluate 3-month functional outcomes. APACHE II scores, SAPS II scores, and our novel scores at 24 hours and 72 hours in N-ICU were obtained. We compared the prognostic performance of our score with APACHE II and SAPS II.
resultsWe developed a 44-point scoring system named the INCNS score, and it includes 19 items which were categorized into five parts: inflammation (I), nutrition (N), consciousness (C), neurological function (N), and systemic function (S). We validated the INCNS score with a cohort of 941 N-ICU patients. The 72-hours INCNS score achieved an area under the receiver operating characteristic curve (AUC) of 0.828 (95% CI: 0.802-0.854), and the 24-hours INCNS score achieved an AUC of 0.788 (95% CI: 0.759-0.817). The INCNS score exhibited significantly better discriminative and prognostic performance than APACHE II and SAPS II at both 24 hours and 72 hours in N-ICU.
conclusionWe developed an INCNS score with superior predictive power for functional outcome of neurocritically ill patients.
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