Evidence map›Paper›PMID 30968475›Full record

ArticleProtein science : a publication of the Protein Society2019

A structural and functional analysis of the glycosyltransferase BshA from Staphylococcus aureus: Insights into the reaction mechanism and regulation of bacillithiol production.

Christopher J Royer, Paul D Cook

Open access · bronzeAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Exploring Daptomycin Hypersensitivity inInternational journal of molecular sciences · 2025
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  9. Article
  10. Molecules (Basel, Switzerland) · 2022
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher J RoyerDepartment of Chemistry, Grand Valley State University, Allendale, Michigan.
Paul D CookDepartment of Chemistry, Grand Valley State University, Allendale, Michigan.ORCID 0000-0002-7286-2860
Grand Valley State University · US

Funding

Studies of the bacillithiol biosynthesis and utilization enzymesR15GM117488 · NIGMS · GRAND VALLEY STATE UNIVERSITY · PI COOK, PAUL D. · 2016 to 2020
$767k
NIGMS NIH HHS 1R15GM117488NIGMS NIH HHS R15 GM117488
6 · The paper itself

Abstract

Bacillithiol is a glucosamine-derived antioxidant found in several pathogenic Gram-positive bacteria. The compound is involved in maintaining the appropriate redox state within the cell as well as detoxifying foreign agents like the antibiotic fosfomycin. Bacillithiol is produced via the action of three enzymes, including BshA, a retaining GT-B glycosyltransferase that utilizes UDP-N-acetylglucosamine and l-malate to produce N-acetylglucosaminyl-malate. Recent studies suggest that retaining GT-B glycosyltransferases like BshA utilize a substrate-assisted mechanism that goes through an S

Indexed as

GlycosyltransferasesCarbohydrate ConformationCrystallography, X-RayCysteineGlucosamineKineticsModels, MolecularStaphylococcus aureusbacillithiolCysteineGlucosamineGlycosyltransferasesbacillithiolfeedback inhibitionfosfomycinglycosyltransferaseGram-positivelow-molecular-weight thiolX-ray crystallography

Identifiers

PMID30968475
PMCPMC6511738
OpenAlexW2936876287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.