ArticleJournal of pineal research2019
Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus.
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Article in Journal of pineal research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Nutraceuticals as modulators of genetic, epigenetic and hormonal factors in obesity.European journal of clinical nutrition · 2026Review
- The role of agomelatine in appetite regulation and body weight in rats.Experimental physiology · 2026Article
- Cave evolution on repeat: reuse of the same genomic regions across lineages but not across traits inbioRxiv : the preprint server for biology · 2026Article
- Leptin receptor rs1137101 polymorphism and altered leptin-sOb-R axis contribute to type 2 diabetes risk in Gujarat population.Frontiers in endocrinology · 2026Article
- Melatonin receptor 1 signaling modulates the metabolic response to high-fat diet in female melatonin-proficient mice.Frontiers in endocrinology · 2026Article
- The Influence of the Sympathetic Nervous System on Cardiometabolic Health in Response to Weight Gain or Weight Loss.Metabolites · 2025Review
- Eating during the biological night is associated with nausea.Sleep health · 2024Article
- Influence of Leptin on the Secretion of Growth Hormone in Ewes under Different Photoperiodic Conditions.International journal of molecular sciences · 2023Article
- Leptin, Adiponectin, and Melatonin Modulate Colostrum Lymphocytes in Mothers with Obesity.International journal of molecular sciences · 2023Article
- The Role of the Melatoninergic System in Circadian and Seasonal Rhythms-Insights From Different Mouse Strains.Frontiers in physiology · 2022Review
- The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease.International journal of biological sciences · 2022Review
- Therapeutic Target Analysis and Molecular Mechanism of Melatonin - Treated Leptin Resistance Induced Obesity: A Systematic Study of Network Pharmacology.Frontiers in endocrinology · 2022Article
- Acute impact of light at night and exogenous melatonin on subjective appetite and plasma leptin.Frontiers in nutrition · 2022Article
- Mechanisms of Melatonin in Obesity: A Review.International journal of molecular sciences · 2021Review
- Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.ACS pharmacology & translational science · 2021Article
- Nontraditional Risk Factors for Obesity in Modern Society.Journal of obesity & metabolic syndrome · 2021Review
- Impaired Leptin Signalling in Obesity: Is Leptin a New Thermolipokine?International journal of molecular sciences · 2021Review
- Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.Nutrition & metabolism · 2021Article
- Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption.Endocrinology, diabetes & metabolism · 2021Article
- NADTheranostics · 2021Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Daniella BuonfiglioDepartment of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo (USP), São Paulo, Brazil.
Cynthia TchioDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.
Isadora FurigoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo (USP), São Paulo, Brazil.
José DonatoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo (USP), São Paulo, Brazil.
Kenkichi BabaDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.
José Cipolla-NetoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences-I, University of São Paulo (USP), São Paulo, Brazil.ORCID https://orcid.org/0000-0003-3748-3731
Gianluca TosiniDepartment of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.ORCID https://orcid.org/0000-0003-3645-4533
Universidade de São Paulo · BRMorehouse School of Medicine · US
Funding
Morehouse School of Medicine Center of Excellence Research Endowment ProgramS21MD000101 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MONTGOMERY-RICE, VALERIE C. · 2001 to 2015
$74.3MTRANSCRIPTION FACTORS AND PROSTATE CANCERG12RR003034 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI ZHAO, XUEYING · 1986 to 2011
$32.4MTRANSPLANTATION OF EXOSOMES FROM HYPOXIA-PRECONDITIONED ADIPOSE-DERIVED STEM CELLS PROMOTES ANGIOGENESIS IN ISCHEMIC HEARTG12MD007602 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI BOND, VINCENT C · 2012 to 2017
$18.4MWARCEFU54RR026137 · NCRR · MOREHOUSE SCHOOL OF MEDICINE · PI HARRIS-HOOKER, SANDRA · 2009 to 2011
$14.6MOXYTOCIN CONTROL OF AGONIST BEHAVIOR IN MALE HAMSTERSU54NS034194 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MACLEISH, PETER R. · 1994 to 2007
$11.5MProgram Evaluation - Internal & External U54NS083932 · NINDS · MOREHOUSE SCHOOL OF MEDICINE · PI MACLEISH, PETER RAYMOND · 2013 to 2017
$7.7MRenewal Application for Clinical Research Education and Career Development (CRECDR25MD007589 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI PRISCILLA E PEMU, Alexander Quarshie · 2012 to 2026
$5.4MT32 Training Program for Institutions That Promote Diversity from Morehouse School of MedicineT32HL103104 · NHLBI · MOREHOUSE SCHOOL OF MEDICINE · PI QUARSHIE, ALEXANDER, TOSINI, GIANLUCA · 2010 to 2021
$2.1MCircadian regulation of RPE functionsR01EY026291 · NEI · MOREHOUSE SCHOOL OF MEDICINE · PI TOSINI, GIANLUCA · 2016 to 2020
$2.1MRetinal Circadian Rhythms and Photoreceptors ViabilitySC2GM116760 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI BABA, KENKICHI · 2016 to 2018
$426kNCRR NIH HHS G12 RR003034NCRR NIH HHS U54 RR026137NEI NIH HHS R01 EY026291NHLBI NIH HHS T32 HL103104NIGMS NIH HHS SC2 GM116760NIH HHS EY026291NIH HHS GM116760NIH HHS T-103104NIMHD NIH HHS G12 MD007602NIMHD NIH HHS R25 MD007589NIMHD NIH HHS S21 MD000101NINDS NIH HHS U54 NS034194NINDS NIH HHS U54 NS083932
Abstract
Recent studies have highlighted the involvement of melatonin in the regulation of energy homeostasis. In this study, we report that mice lacking melatonin receptor 1 (MT
Indexed as
Signal TransductionAnimalsArcuate Nucleus of HypothalamusGene DeletionLeptinMaleMiceMice, KnockoutReceptor, Melatonin, MT1LeptinReceptor, Melatonin, MT1leptin receptorleptin resistancemelatoninmelatonin receptor 1metabolismobesity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.