ReviewHuman genetics2019
A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers.
Review in Human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Gene-Air Pollution Interaction in Cardiovascular Disease: Lights and Shadows in a Tangled Risk Factor Network.International journal of molecular sciences · 2026Review
- Epidemiological and bioinformatics analyses of air pollution and genetic susceptibility in aortic stenosis risk.Nature communications · 2026Article
- Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study.PloS one · 2026Article
- Heart rate variability associated with depression and lung decline in chronic obstructive pulmonary disease: Mechanisms and interventions.World journal of psychiatry · 2025Article
- Air Pollution and Its Impact on Health and Performance in Football Players.Sports (Basel, Switzerland) · 2025Review
- Oxidative gaseous air pollutant exposure interacts with PNPLA3-I148M genotype to influence liver fat fraction and multi-omics profiles in young adults.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Combined Effect of Air Pollution and Genetic Risk on Incident Cardiovascular Diseases.Journal of the American Heart Association · 2024Article
- The micro-743a-3p-GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice.Cellular & molecular biology letters · 2024Article
- Article
- Effects of PMFrontiers in public health · 2024Article
- Mendelian randomization study supports the causal effects of air pollution on longevity via multiple age-related diseases.npj aging · 2023Article
- Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions.Environmental pollution (Barking, Essex : 1987) · 2023Review
- Review
- Association of air pollution exposure and increased coronary artery disease risk: the modifying effect of genetic susceptibility.Environmental health : a global access science source · 2023Article
- Air pollution, genetic susceptibility, and the risk of atrial fibrillation: A large prospective cohort study.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- circCIMT Silencing Promotes Cadmium-Induced Malignant Transformation of Lung Epithelial Cells Through the DNA Base Excision Repair Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Air pollution associated acute respiratory inflammation and modification by GSTM1 and GSTT1 gene polymorphisms: a panel study of healthy undergraduates.Environmental health : a global access science source · 2023Article
- Criteria air pollutants and hospitalizations of a wide spectrum of cardiovascular diseases: A nationwide case-crossover study in China.Eco-Environment & Health · 2022Article
- Ambient air pollution, healthy diet and vegetable intakes, and mortality: a prospective UK Biobank study.International journal of epidemiology · 2022Article
- Social Determinants of Health Factors for Gene-Environment COVID-19 Research: Challenges and Opportunities.Advanced genetics (Hoboken, N.J.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Air pollution is recognized as causal factor for cardiovascular disease (CVD) and is associated with multiple CVD risk factors. Substantial research effort has been invested in understanding the linkages between genetic variation and CVD risk, resulting in over 50 CVD-associated genetic loci. More recently, gene-air pollution interaction studies have quantified the contribution of genetic variation to inter-individual heterogeneity in air pollution health risks, and aided in elucidating mechanisms of air pollution exposure health risks. Here, we perform a comprehensive review of gene-air pollution interaction studies for CVD, as well as risk factors and emerging CVD biomarkers. The literature review revealed that most published interaction studies have been candidate gene studies, causing observed interactions to cluster in a few genes related to detoxification (GSTM1 and GSTT1), inflammation (IL-6), iron processing (HFE), and microRNA processing (GEMIN4 and DGCR8). There have been a few genome-wide interaction studies with results indicating that interactions extend beyond commonly considered genetic loci. Gene-air pollution interactions are observed for exposure periods ranging from hours to years and a variety of air pollutants including particulate matter, gaseous pollutants, and pollutant sources such as traffic. Though the existing evidence for the existence of relevant gene-air pollution interactions for CVD outcomes is substantial, it could be strengthened by improved replication and meta-analyses as well as functional validation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.