ArticlePharmaceutical research2019
Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate.
Article in Pharmaceutical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- Discrete Element Method Evaluation of Triboelectric Charging Due to Powder Handling in the Capsule of a DPI.Pharmaceutics · 2023Article
- Assessment of Tribo-charging and Continuous Feeding Performance of Direct Compression Grades of Isomalt and Mannitol Powders.AAPS PharmSciTech · 2023Article
- On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients.International journal of pharmaceutics: X · 2021Article
- Particle-based coarse-grained approach for simulating dry powder inhaler.International journal of pharmaceutics · 2021Article
- Co-Amorphization of Kanamycin with Amino Acids Improves Aerosolization.Pharmaceutics · 2020Article
- Evaluation of the Physico-mechanical Properties and Electrostatic Charging Behavior of Different Capsule Types for Inhalation Under Distinct Environmental Conditions.AAPS PharmSciTech · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeThe performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery.
methodsSalbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe.
resultsThe spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet milled SBS (crystalline and acicular) that charged negatively and to a lower extent. D-mannitol charged positively and to a higher extent than the APIs. All drug-excipient blends charged negatively and differences were found between the spray-dried and jet milled SBS blends at 2% and 5% drug loads.
conclusionsIt was demonstrated how distinct solid-states, particle shape, size and morphology as well as different water contents of the different materials can affect tribo-charging. For their binary blends, the amount and nature of fines seem to govern inter-particle contacts critically impacting charge evolution.
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Registered trials
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