ArticleMolecular biology and evolution2019
Dynamics of Transposable Element Invasions with piRNA Clusters.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 85 citations in OpenAlex.
- Cooperation, competition and enforcement in transposon evolution.Nature communications · 2026Article
- Adaptive P-element Insertions in a Long Non-Coding RNA are Potential Emerging piRNA Clusters.Genome biology and evolution · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- Article
- Rapid evolution and comparative analysis of piRNA clusters inbioRxiv : the preprint server for biology · 2026Article
- piR-hsa-022095 Drives Hypertrophic Scar Formation via KLF11-Dependent Fibroblast Proliferation.Biomedicines · 2025Article
- The impact of insertion bias into piRNA clusters on the invasion of transposable elements.BMC biology · 2025Article
- Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence.PLoS genetics · 2025Article
- Purifying selection shapes the dynamics of P-element invasion in Drosophila simulans populations.Genome biology · 2025Article
- Ecological Niche Adaptations Influence Transposable Element Dynamics in Pollinating and Non-Pollinating Fig Wasps.Ecology and evolution · 2025Article
- Evolution of piRNA-guided defense against transposable elements.Trends in genetics : TIG · 2025Review
- On the origin of the P-element invasion in Drosophila simulans.Mobile DNA · 2025Article
- Comprehensive analysis ofTranslational andrology and urology · 2024Article
- Rapid evolution of piRNA clusters in theGenome research · 2024Article
- Experimentally evolvingGenome research · 2024Article
- Blessing or curse: how the epigenetic resolution of host-transposable element conflicts shapes their evolutionary dynamics.Proceedings. Biological sciences · 2024Article
- Spoink, a LTR retrotransposon, invaded D. melanogaster populations in the 1990s.PLoS genetics · 2024Article
- Article
- Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases.Cell communication and signaling : CCS · 2023Review
- Unistrand piRNA clusters are an evolutionarily conserved mechanism to suppress endogenous retroviruses across the Drosophila genus.Nature communications · 2023Article
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1 author.
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Abstract
In mammals and invertebrates, the proliferation of an invading transposable element (TE) is thought to be stopped by an insertion into a piRNA cluster. Here, we explore the dynamics of TE invasions under this trap model using computer simulations. We found that piRNA clusters confer a substantial benefit, effectively preventing extinction of host populations from a proliferation of deleterious TEs. TE invasions consist of three distinct phases: first, the TE amplifies within the population, next TE proliferation is stopped by segregating cluster insertions, and finally the TE is inactivated by fixation of a cluster insertion. Suppression by segregating cluster insertions is unstable and bursts of TE activity may yet occur. The transposition rate and the population size mostly influence the length of the phases but not the amount of TEs accumulating during an invasion. Solely, the size of piRNA clusters was identified as a major factor influencing TE abundance. We found that a single nonrecombining cluster is more efficient in stopping invasions than clusters distributed over several chromosomes. Recombination among cluster sites makes it necessary that each diploid carries, on the average, four cluster insertions to stop an invasion. Surprisingly, negative selection in a model with piRNA clusters can lead to a novel equilibrium state, where TE copy numbers remain stable despite only some individuals in a population carrying a cluster insertion. In Drosophila melanogaster, the trap model accounts for the abundance of TEs produced in the germline but fails to predict the abundance of TEs produced in the soma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.