ArticleFrontiers in immunology2019
Antigenic Mimicry in Paraneoplastic Immune Thrombocytopenia.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Efficacy and safety of eltrombopag in the treatment of cancer therapy-induced thrombocytopenia: a large-scale, multicenter, retrospective study in China.Blood science (Baltimore, Md.) · 2026Article
- Successful eltrombopag discontinuation in paraneoplastic immune thrombocytopenia: a case report.Blood vessels, thrombosis & hemostasis · 2026Article
- Primary renal mucosa-associated lymphoid tissue lymphoma coexisting with immune thrombocytopenia.World journal of surgical oncology · 2025Article
- The Proteome of Antibody-Mediated Rejection: From Glomerulitis to Transplant Glomerulopathy.Biomedicines · 2022Article
- Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction.Translational oncology · 2021Review
- Understanding Immune Thrombocytopenia: Looking Out of the Box.Frontiers in medicine · 2021Review
- ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice.Hepatology communications · 2020Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of immune thrombocytopenia (ITP) with cancer has been reported, but the causality of tumor cells in paraneoplastic ITP pathogenesis and maintenance has never been established. We analyzed the unusual case of refractory ITP and coincident urothelial tumor of the kidney with circulating high titer anti-GPIIBIIIA autoantibodies. Intriguingly, after nephrectomy, the patient recovered fully and her anti-GPIIBIIIA autoantibodies disappeared. Proteomic and immunohistochemistry analyses revealed erratic GPIIB expression by the tumor cells, suggesting possible antigenic mimicry chronically stimulating the immune system and leading to this patient's refractory ITP. Such previously unreported findings provide proof-of-concept that requires further confirmation with the prospective study of a larger number of patients.
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Registered trials
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