ReviewFrontiers in endocrinology2019
Overt and Subclinical Hypothyroidism in the Elderly: When to Treat?
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults.The Journal of clinical endocrinology and metabolism · 2024Trial
- Review
- Article
- Association between monocyte to high-density lipoprotein cholesterol ratio and thyroid function: a cross-sectional study.Scientific reports · 2025Article
- V-PRO Blood Collection Tubes: Validation for Clinical Chemistry and Immunoassay Tests.Journal of clinical laboratory analysis · 2025Article
- Thyroid and reproductive hormonal factors associated with menorrhagia among women in Kenya.African journal of laboratory medicine · 2025Article
- The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007-2012.BMC endocrine disorders · 2024Article
- Association between serum Klotho levels and hypothyroidism in older adults: NHANES 2007-2012.Scientific reports · 2024Article
- Elevation of free triiodothyronine (fT3) levels by Plasmodium falciparum independent of thyroid stimulating hormone (TSH) in children with uncomplicated malaria.Journal of clinical laboratory analysis · 2024Article
- Appropriateness of Levothyroxine Prescription: A Multicenter Retrospective Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Association between Subclinical Hypothyroidism and Glycemic Control in Older Adults in a Medical Center in Peru.Current gerontology and geriatrics research · 2024Article
- A review of complex hormone regulation in thyroid cancer: novel insights beyond the hypothalamus-pituitary-thyroid axis.Frontiers in endocrinology · 2024Review
- Individual Features of the Hypothalamic-Pituitary-Thyroid Axis Functioning during Aging in Non-Human Primates.Bulletin of experimental biology and medicine · 2023Article
- Non-medicalization of medical science: Rationalization for future.World journal of methodology · 2022Review
- Cross-Talk between the Cytokine IL-37 and Thyroid Hormones in Modulating Chronic Inflammation Associated with Target Organ Damage in Age-Related Metabolic and Vascular Conditions.International journal of molecular sciences · 2022Review
- Thyroid disorders and cardiovascular manifestations: an update.Endocrine · 2022Review
- Effect of Subclinical Hypothyroidism on the Association between Hemoglobin A1c and Reduced Renal Function: A Prospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Use of levothyroxine in the management of hypothyroidism: A historical perspective.Frontiers in endocrinology · 2022Review
- Prevalence and risk factors of untreated thyroid dysfunctions in the older Caucasian adults: Results of PolSenior 2 survey.PloS one · 2022Article
- A practical contemporary approach to decision-making on subclinical hypothyroidism.Archives of endocrinology and metabolism · 2021Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothyroidism is characterized by increased thyrotropin (TSH) levels and reduced free thyroid hormone fractions while, subclinical hypothyroidism (sHT) by elevated serum TSH in the face of normal thyroid hormones. The high frequency of hypothyroidism among the general population in Western Countries made levothyroxine (LT4) one of the 10 most prescribed drugs. However, circulating TSH has been demonstrated to increase with aging, regardless the existence of an actual thyroid disease. Thus, when confronting an increase in circulating TSH levels in the elderly, especially in the oldest old, it is important to carry an appropriate diagnostic path, comprehensive of clinical picture as well as laboratory and imaging techniques. In the current review, we summarize the recommendations for a correct diagnostic workup and therapeutic approach to older people with elevated TSH value, with special attention to the presence of frailty, comorbidities, and poly-therapy. The treatment of choice for hypothyroid patients is hormone replacement with LT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.