Evidence map›Paper›PMID 30967788›Full record

ArticleFrontiers in physiology2019

Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D.

Xin Zhou, Alfonso Bueno-Orovio, Richard J Schilling, Claire Kirkby, Chris Denning, Divya Rajamohan, Kevin Burrage, Andrew Tinker, Blanca Rodriguez, Stephen C Harmer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. NovelFrontiers in physiology · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. ArrhythmoGenoPharmacoTherapy.Frontiers in pharmacology · 2020
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Xin ZhouDepartment of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Alfonso Bueno-OrovioDepartment of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Richard J SchillingSt Bartholomew's Hospital, London, United Kingdom.
Claire KirkbySt Bartholomew's Hospital, London, United Kingdom.
Chris DenningDepartment of Stem Cell Biology, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.
Divya RajamohanDepartment of Stem Cell Biology, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.
Kevin BurrageDepartment of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Andrew TinkerThe William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Blanca RodriguezDepartment of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, United Kingdom.
Stephen C HarmerThe William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
University of Oxford · GBSt Bartholomew's Hospital · GBUniversity of Nottingham · GBBritish Heart Foundation · GBQueen Mary University of London · GBWilliam Harvey Research Institute · GB

Funding

British Heart Foundation FS/12/21/29482British Heart Foundation FS/12/59/29756British Heart Foundation FS/16/30/32162British Heart Foundation FS/17/22/32644British Heart Foundation PG/14/59/31000British Heart Foundation RG/14/1/30588British Heart Foundation RG/15/6/31436British Heart Foundation SP/15/9/31605Medical Research Council MR/M017354/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013105/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C013202/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K000225/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/P001076/1Wellcome Trust
6 · The paper itself

Abstract

The congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder that can cause sudden cardiac death. LQT1 is a subtype of LQTS caused by mutations in KCNQ1, affecting the slow delayed-rectifier potassium current (

Indexed as

arrhythmiacomputational biologygain-of-functionKCNQ1long QT syndromesinus node

Identifiers

PMID30967788
PMCPMC6430739
OpenAlexW2920950463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.