SynthesisScientific reports2019
Gallstone Disease and the Risk of Cardiovascular Disease.
Synthesis in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05618626 (Cardiovascular Diseases), which is not on this map. Cited by 22 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Diseases (CVD) and Nonalcoholic Fatty Liver Diseases (NAFLD) Among Gallstone and Cholecystectomy Patients and the Impact of a Novel Diet and Muscle Training Program
Who cites it
22 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Estimating global prevalence of gallbladder stones in general population from 2000 to 2024: systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Pooled it
- The Association between Gallstone Disease and Cardiovascular Disease: A Systematic Review and Meta-Analysis.Reviews on recent clinical trials · 2025Pooled it
- Association Between Gallstone Disease and Risk of Mortality of Cardiovascular Disease and Cancer: A Systematic Review and Meta-Analysis.Cardiovascular & hematological disorders drug targets · 2024Pooled it
- Pooled it
- Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses.BMC medicine · 2023Pooled it
- Association between hepatic steatosis index and gallstones in US adults: A cross-sectional study of NHANES 2017-2020.Medicine · 2026Article
- A lower LDL-c/ApoB ratio is associated with an increased prevalence of gallstones in the regional Chinese adult population, according to a retrospective, propensity-matched analysis.Frontiers in physiology · 2026Article
- Mortality and cardiovascular disease after cholecystectomy in type 2 diabetes: A nationwide longitudinal cohort study.Journal of hepato-biliary-pancreatic sciences · 2025Article
- [Establishment and Validation of a Predictive Model for Gallstone Disease in the General Population: A Multicenter Study].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- [New Progress in Longitudinal Research on the Risk Factors for Cholelithiasis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study.Scientific reports · 2024Article
- Association of Cardiovascular Disease and Pancreatitis: What Came First, the Chicken or the Egg?Journal of clinical medicine · 2023Review
- Impact of cholecystectomy on acute coronary syndrome according to metabolic condition: a nationwide population-based cohort study.Scientific reports · 2023Article
- Gallbladder disease is associated with the risk of cardiovascular disease among Uyghurs in Xinjiang: a prospective cohort study.BMC public health · 2023Article
- Acute Kidney Injury after Endoscopic Retrograde Cholangiopancreatography-A Hospital-Based Prospective Observational Study.Biomedicines · 2022Article
- Cholecystectomy reduces the risk of myocardial and cerebral infarction in patients with gallstone-related infection.Scientific reports · 2022Article
- The association between hypertension and the risk of gallstone disease: a cross-sectional study.BMC gastroenterology · 2022Article
- Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study.PloS one · 2022Article
- Development of a prognostic prediction model based on a combined multi-omics analysis of head and neck squamous cell carcinoma cell pyroptosis-related genes.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallstone disease (GD) is one of the most common presentations to surgical units worldwide and shares several risk factors with cardiovascular disease (CVD). CVD remains the most common cause of death worldwide and results in considerable economic burden. Recent observational studies have demonstrated an association between GD and CVD with some studies demonstrating a stronger association with cholecystectomy. We present the findings of a meta-analysis assessing the relationship between GD and CVD. A total of fourteen cohort studies with over 1.2 million participants were included. The pooled hazard ratio (HR, 95% confidence interval [CI]) for association with GD from a random-effects model is 1.23 (95%CI: 1.16-1.30) for fatal and non-fatal CVD events. The association was present in females and males. Three studies report the relationship between cholecystectomy and CVD with a pooled HR of 1.41 (95%CI: 1.21-1.64) which compares to a HR of 1.30 (95%CI: 1.07-1.58) when cholecystectomy is excluded although confounding may influence this result. Our meta-analysis demonstrates a significant relationship between GD and CVD events which is present in both sexes. Further research is needed to assess the influence of cholecystectomy on this association.
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