ArticleScientific reports2019
Impact of systemic vascular risk factors on the choriocapillaris using optical coherence tomography angiography in patients with systemic hypertension.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Choriocapillaris Perfusion after 8 Weeks of High-Speed Circuit Training in Older Healthy Adults.Current eye research · 2024Trial
- Choriocapillaris Flow-Enriched Prediction of Retinal Sensitivity Using OCT-Derived Biomarkers in Intermediate Age-Related Macular Degeneration.Journal of clinical medicine · 2026Article
- Ocular Microvascular Changes in Offspring Born to Mothers With Gestational Diabetes Mellitus: The Nanjing Eye Study.Translational vision science & technology · 2025Article
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- Relationship Between Renal Resistive Index and Retinal Vascular Density in Individuals with Hypertension.Biomedicines · 2025Article
- Comparing Optical Coherence Tomography Angiography Metrics in Healthy Chinese and Caucasian Adults.Journal of personalized medicine · 2024Article
- Ocular perfusion pressure is not reduced in response to lower body negative pressure.NPJ microgravity · 2024Article
- Associations between the retinal/choroidal microvasculature and carotid plaque in patients with CAD: An OCTA study.Heliyon · 2024Article
- Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques.Journal of personalized medicine · 2023Review
- Correlation Between Coronary and Retinal Microangiopathy in Patients With STEMI.Translational vision science & technology · 2023Article
- Analysis of Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) Parameters in Young Adults after SARS-CoV-2 Infection (COVID-19) Compared with Healthy Young Controls.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Retinochoroidal microvascular changes in newly developed obese children: an optical coherence tomography angiography study.BMC ophthalmology · 2022Article
- Associations between Choriocapillaris Flow on Optical Coherence Tomography Angiography and Cardiovascular Risk Profiles of Patients with Acute Myocardial Infarction.Journal of personalized medicine · 2022Article
- Hypertensive eye disease.Nature reviews. Disease primers · 2022Review
- Characterization of Choriocapillaris and Choroidal Abnormalities in Alport Syndrome.Translational vision science & technology · 2022Article
- Corneal endothelial cell density and microvascular changes of retina and optic disc in autosomal dominant polycystic kidney disease.Indian journal of ophthalmology · 2021Article
- Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope.The British journal of ophthalmology · 2021Article
- Choriocapillaris microvasculature dysfunction in systemic hypertension.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the characteristics of the choriocapillaris flow voids using optical coherence tomography angiography (OCTA) in 85 patients (164 eyes) with hypertension (mean ± SD age, 56 ± 11 years; 45% women; 20% poorly controlled BP; 16% diabetes) who are without ocular diseases and determined possible correlations with systemic vascular risk factors. Data on 24-hour ambulatory blood pressure (BP), serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. OCTA imaging (6 × 6 mm scans; AngioVue) with quantitative microvascular analysis of the choriocapillaris was performed. Linear regression was used to investigate the association of systemic risk factors with area (percentage), size (pixels) and number of choriocapillaris flow voids. Diabetes (β = 0.33; 95% CI, 0.02 to 0.63) and daytime systolic BP (β = -0.13; 95% CI, -0.24 to -0.02) were associated with areas of flow voids. Age (β = 0.21; 95% CI, 0.06 to 0.36) and daytime diastolic BP (β = -0.18; 95% CI, -0.34 to -0.02) were associated with size of flow voids. Age (β = -21.21; 95% CI, -31.79 to -10.63) and nighttime diastolic BP (β = 13.89; 95% CI, 0.61 to 27.17) were associated with number of flow voids. Kidney parameters were not associated with any features of flow voids. In patients with hypertension, a higher BP appeared to increase blood flow in the choriocapillaris which needs to be considered when using the OCTA to study eye diseases in hypertensives.
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