Evidence map›Paper›PMID 30967509›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Untangling posterior growth and segmentation by analyzing mechanisms of axis elongation in hemichordates.

Jens H Fritzenwanker, Kevin R Uhlinger, John Gerhart, Elena Silva, Christopher J Lowe

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. An Increase in Animal Diversity was Facilitated by Ecologically-Driven Brain Complexity Throughout the Cambrian.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Secreted Frizzled-related proteins in animal development.Histochemistry and cell biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Extensive loss of Wnt genes in Tardigrada.BMC ecology and evolution · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Review
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jens H FritzenwankerHopkins Marine Station, Stanford University, Pacific Grove, CA 93950; jens.fritzenwanker@gmail.com.ORCID 0000-0002-5201-4100
Kevin R UhlingerHopkins Marine Station, Stanford University, Pacific Grove, CA 93950.
John GerhartDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Elena SilvaDepartment of Biology, Georgetown University, Washington, DC 20057.
Christopher J LoweHopkins Marine Station, Stanford University, Pacific Grove, CA 93950.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The trunk is a key feature of the bilaterian body plan. Despite spectacular morphological diversity in bilaterian trunk anatomies, most insights into trunk development are from segmented taxa, namely arthropods and chordates. Mechanisms of posterior axis elongation (PAE) and segmentation are tightly coupled in arthropods and vertebrates, making it challenging to differentiate between the underlying developmental mechanisms specific to each process. Investigating trunk elongation in unsegmented animals facilitates examination of mechanisms specific to PAE and provides a different perspective for testing hypotheses of bilaterian trunk evolution. Here we investigate the developmental roles of canonical Wnt and Notch signaling in the hemichordate

Indexed as

Body PatterningChordata, NonvertebrateGene Expression Regulation, DevelopmentalAnimalsEmbryonic DevelopmentEmbryo, NonmammalianReceptors, NotchWnt Signaling PathwayReceptors, NotchhemichordatesNotch signalingposterior axis elongationposterior growthWnt signaling

Identifiers

PMID30967509
PMCPMC6486776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.