Evidence map›Paper›PMID 30967472›Full record

ArticleThe Journal of biological chemistry2019

The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors.

Tianwen Huang, Yasmilde Rodríguez González, Dianbo Qu, En Huang, Farzaneh Safarpour, Eugene Wang, Alvin Joselin, Doo Soon Im, Steve M Callaghan, Wassamon Boonying and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Resistance of E2F4DN to p38Scientific reports · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Genetic Variants ofJournal of cardiovascular development and disease · 2022
    Article
  9. The E2F1-IREB2 axis regulates neuronal ferroptosis in cerebral ischemia.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 4 countries.

Tianwen HuangUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada; Department of Neurology, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University Union Hospital, Fuzhou, 350001 Fujian, China.
Yasmilde Rodríguez GonzálezUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Dianbo QuUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada; Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
En HuangUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Farzaneh SafarpourUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Eugene WangUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Alvin JoselinUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada; Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Doo Soon ImUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada; Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Steve M CallaghanUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Wassamon BoonyingUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Lisa JulianUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Sally L DunwoodieVictor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia; Faculties of Medicine and Science University of New South Wales, Kensington, New South Wales 2033, Australia.
Ruth S SlackUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
David S ParkUniversity of Ottawa Brain and Mind Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada; Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada. Electronic address: david.park1@ucalgary.ca.
University of Ottawa · CAFujian Medical University · CNVictor Chang Cardiac Research Institute · AU

Funding

CIHR
6 · The paper itself

Abstract

We previously reported that the cell cycle-related cyclin-dependent kinase 4-retinoblastoma (RB) transcriptional corepressor pathway is essential for stroke-induced cell death both

Indexed as

Gene Expression RegulationAmino Acid MotifsAnimalsCell DeathE2F1 Transcription FactorE2F4 Transcription FactorMiceMice, TransgenicNeuronsRepressor ProteinsStrokeTrans-ActivatorsCited2 protein, mouseE2f1 protein, mouseE2F1 Transcription FactorE2f4 protein, mouseE2F4 Transcription FactorRepressor ProteinsTrans-Activatorsbrain injuryCbp/P300-interacting transactivator with Glu/Asp–rich carboxyl-terminal domain 2cell deathE2F transcription factorgene promotergene regulationhypoxiaischemianeuronstroke

Identifiers

PMID30967472
PMCPMC6544850
OpenAlexW2936239723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.