ArticlemBio2019
Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture.
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In one paragraph
Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 30 citations in OpenAlex.
- Impact of oralmSystems · 2025Article
- Obligate intracellular bacteria and host cell death pathways-the matter of life and death.Cell and tissue research · 2025Review
- ThebioRxiv : the preprint server for biology · 2025Article
- Genome-wide identification of modulators of Chlamydia trachomatis parasitophorous vacuole stability highlights an important role for sphingolipid supply.PLoS biology · 2025Article
- Infectivity of a pathogenicity-attenuatedInfection and immunity · 2025Article
- A platform supporting generation and isolation of random transposon mutants inJournal of bacteriology · 2025Article
- Isolation and characterization of a Chlamydia muridarum tc0237 mutant from a genetic screen that is attenuated in epithelial cells.PloS one · 2025Article
- Tail-specific protease is an essentialInfection and immunity · 2024Article
- Advances in vaccine development for Chlamydia trachomatis.Pathogens and disease · 2024Review
- Restriction and evasion: a review of IFNγ-mediated cell-autonomous defense pathways during genital Chlamydia infection.Pathogens and disease · 2024Review
- IL-23 receptor signaling licenses group 3-like innate lymphoid cells to restrict a live-attenuated oral Chlamydia vaccine in the gut.Infection and immunity · 2023Article
- The emerging complexity of Chlamydia trachomatis interactions with host cells as revealed by molecular genetic approaches.Current opinion in microbiology · 2023Review
- Regulation of chlamydial colonization by IFNγ delivered via distinct cells.Trends in microbiology · 2023Review
- IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection.Microorganisms · 2023Article
- The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.Cell host & microbe · 2022Article
- Th1 cells are dispensable for primary clearance of Chlamydia from the female reproductive tract of mice.PLoS pathogens · 2022Article
- IL-21/IL-21R Regulates the Neutrophil-Mediated Pathologic Immune Response during Chlamydial Respiratory Infection.Mediators of inflammation · 2022Article
- Inter-species lateral gene transfer focused on the Chlamydia plasticity zone identifies loci associated with immediate cytotoxicity and inclusion stability.Molecular microbiology · 2021Article
- Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization.Trends in microbiology · 2021Review
- The growing repertoire of genetic tools for dissecting chlamydial pathogenesis.Pathogens and disease · 2021Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Amanda M Giebel *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Shuai Hu *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Krithika Rajaram *Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ryan FinethyDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Evelyn TohDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Julie A BrothwellDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sandra G MorrisonDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Robert J SuchlandDivision of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle, Washington, USA.
Barry D SteinDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Jörn CoersDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Richard P MorrisonDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA rpmorrison@uams.edu nelsonde@indiana.edu.ORCID 0000-0002-9747-9884
David E NelsonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA rpmorrison@uams.edu nelsonde@indiana.edu.
Indiana University School of MedicineDuke University · USUniversity of Arkansas for Medical Sciences · USIndiana University Bloomington · USUniversity of Washington · US
Funding
Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5MGenetic analysis of mechanisms of chlamydial immune evasionR01AI099278 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI NELSON, DAVID EMMET · 2012 to 2023
$4.6MIRGM-driven host responses to Chlamydia trachomatis infectionsR01AI103197 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN · 2013 to 2023
$4.2MTraining in STIs and infections of global health significanceT32AI007637 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI WOOLS-KALOUSTIAN, KARA KAY · 2001 to 2020
$3.4MInterferon-inducible cell-intrinsic host defense against Chlamydia trachomatisR37AI103197 · NIAID · DUKE UNIVERSITY · PI Jorn Coers · 2024 to 2026
$1.6MGenetic analysis of mechanisms of chlamydial immune evasionR56AI099278 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI NELSON, DAVID EMMET · 2017 to 2017
$579kNIAID NIH HHS R01 AI099278NIAID NIH HHS R37 AI103197NIAID NIH HHS R56 AI099278NIAID NIH HHS T32 AI007637NIGMS NIH HHS P20 GM103625
Abstract
Interferon-regulated immune defenses protect mammals from pathogenically diverse obligate intracellular bacterial pathogens of the genus
Indexed as
ApoptosisHost-Pathogen InteractionsImmune EvasionImmunity, InnateAnimalsChlamydia InfectionsChlamydia muridarumDisease Models, AnimalGenetic TestingInclusion BodiesInterferon-gammaMiceInterferon-gammaChlamydiahost-pathogen interactionsinterferon-stimulated genesintracellular pathogensmolecular genetics
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.