Evidence map›Paper›PMID 30967445›Full record

ArticleLife science alliance2019

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Vivien Kmietczyk, Eva Riechert, Laura Kalinski, Etienne Boileau, Ellen Malovrh, Brandon Malone, Agnieszka Gorska, Christoph Hofmann, Eshita Varma, Lonny Jürgensen and 8 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04533282 (Epitranscriptomic Biomarkers for Ischemic Heart Disease), which is not on this map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04533282 unknown statusnot on this mapstarted 2020, after this paper: background citation

Epitranscriptomic Biomarkers for Ischemic Heart Disease (IHD-EPITRAN) - A Prospective Cohort Study

Typeobservational_patient_registrySponsorHospital District of Helsinki and UusimaaRan2020 to 2025Enrolled200ConditionsIschemic Heart Disease, Coronary Artery Disease, Aortic Valve Stenosis, Acute Myocardial InfarctionArmsBlood samples., Collection of right atrial appendage tissue sample., Health Survey, Clinical symptom scaling, Transthoracic echocardiography (TTE)
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 139 citations in OpenAlex.

  1. METTL14-Mediated mAging cell · 2026
    Article
  2. RNA modifications in peripheral blood are associated with acute coronary syndrome.Journal of molecular and cellular cardiology plus · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. The mRNA (New York, N.Y.) · 2025
    Article
  13. METTL3 Modulates Radiation-Induced Cardiac Fibrosis via the Akt/mTOR Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  14. METTL14-mediated mActa pharmacologica Sinica · 2025
    Article
  15. METTL3: a multifunctional regulator in diseases.Molecular and cellular biochemistry · 2025
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Methylations in dilated cardiomyopathy and heart failure.Frontiers in cardiovascular medicine · 2025
    Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Vivien KmietczykDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-4728-4077
Eva RiechertDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-4876-7860
Laura KalinskiDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Etienne BoileauDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0001-9355-0973
Ellen MalovrhDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-0911-6125
Brandon MaloneDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Agnieszka GorskaDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Christoph HofmannDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-3389-6582
Eshita VarmaDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Lonny JürgensenDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Verena Kamuf-SchenkDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Janine AltmüllerCologne Center for Genomics, University Cologne, Cologne, Germany.
Rewati TappuDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Martin BuschDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-2717-7063
Patrick MostDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Hugo A KatusDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Christoph DieterichDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Mirko VölkersDepartment of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany mirko.voelkers@med.uni-heidelberg.de.ORCID 0000-0003-2344-1856
Heidelberg University · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conceptually similar to modifications of DNA, mRNAs undergo chemical modifications, which can affect their activity, localization, and stability. The most prevalent internal modification in mRNA is the methylation of adenosine at the N

Indexed as

Cell EnlargementGene Expression RegulationAdenosineAnimalsCardiomyopathy, DilatedCell ProliferationCells, CulturedCell SizeCohort StudiesGene Knockdown TechniquesHumansMaleMethylationMethyltransferasesMiceMyocytes, CardiacAdenosineMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseRNA, Messenger

Identifiers

PMID30967445
PMCPMC6458851
OpenAlexW2937209865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.