ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Rice stripe virus hitchhikes the vector insect vitellogenin ligand-receptor pathway for ovary entry.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 32 citations in OpenAlex.
- Unveiling the conserved mechanism of microsporidian vertical transmission: A comparative study ofVirulence · 2026Article
- Targeting octopamine synthesis genes LsTDC and LsTβH impairs reproduction, feeding and virus transmission in the small brown planthopper Laodelphax striatellus.Pest management science · 2026Article
- Article
- Loss of vitellogenin receptor function results in yolk depletion, virome expansion, and reduced bacterial load within the oocytes of Rhodnius prolixus.BMC biology · 2026Article
- Exogenous Calcium-Mediated Reinforcement of Cell Wall Represents a Pivotal Mechanism in Rice's Primed Defense Response Against Brown Planthopper Reproduction.Rice (New York, N.Y.) · 2025Article
- The Function of TER94 of Spodoptera frugiperda 9 Cells When Infected With Invertebrate Iridescent Virus-6.Journal of basic microbiology · 2025Article
- Chitin Deacetylase Gene Family Positively Regulates the Accumulation of Rice Stripe Virus inInsects · 2025Article
- Roles of Vitellogenin and Its Receptor Genes in Female Reproduction of the Cigarette Beetle,Insects · 2025Article
- Identification and Characterization of Three Novel Solemo-like Viruses in the White-Backed Planthopper,Insects · 2024Article
- Voltage-dependent anion channel 2 (VDAC2) facilitates the accumulation of rice stripe virus in the vector Laodelphax striatellus.Virus research · 2023Article
- Vitellogenin receptor transports the 30K protein LP1 without cell-penetrating peptide, into the oocytes of the silkworm,Frontiers in physiology · 2023Article
- GrpE is involved in mitochondrial function and is an effective target for RNAi-mediated pest and arbovirus control.Insect molecular biology · 2022Article
- Comparative transcriptome profiling reveals a network of differentially expressed genes in Asia II 7 and MEAM1 whitefly cryptic species in response to early infection ofFrontiers in microbiology · 2022Article
- Sublethal Effects of Imidacloprid on Fecundity, Apoptosis and Virus Transmission in the Small Brown PlanthopperInsects · 2021Article
- The vitellogenin receptor functionality of the migratory locust depends on its phosphorylation by juvenile hormone.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Tick Ecdysteroid Hormone, Global Microbiota/Microorganisms · 2021Article
- The Bunyavirales: The Plant-Infecting Counterparts.Viruses · 2021Review
- Regulatory Mechanisms of Vitellogenesis in Insects.Frontiers in cell and developmental biology · 2020Review
- Overview: biotic signalling for smart pest management.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Vitellogenin Receptor as a Target for Tick Control: A Mini-Review.Frontiers in physiology · 2019Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that plant arboviruses infect insect vector cells by endocytosis; however, the cellular receptors that mediate endocytosis have not been well defined. In our recently published work and this study, by clarifying the vertical transmission mechanism of Rice stripe virus (RSV) in Laodelphax striatellus, we provide a novel paradigm for how arboviruses enter insect germ-line cells. Instead of direct interaction with a viral receptor, the virus binds to a secreted ligand protein, hitchhiking the ligand-receptor pathway to achieve cell entry. Vitellogenin (Vg) is an indispensable protein for embryo development that is synthesized extra-ovarially and taken up by germ-line cells through Vg receptor (VgR)-mediated endocytosis. After revealing that RSV invades L. striatellus ovary by a specific molecular interaction with the insect Vg in haemolymph, this study addressed VgR's function in mediating the RSV invasion of the germarium nurse cells, further confirming the ligand's receptor-mediated viral cell-invasion mechanism. Understanding the viral ovary-entry pathways in vectors will help to find suitable measures to block the trans-generation transmission of the viruses. This article is part of the theme issue 'Biotic signalling sheds light on smart pest management'.
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