ArticleProceedings. Biological sciences2019
The history, genome and biology of NCTC 30: a non-pandemic Vibrio cholerae isolate from World War One.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Tracking a misclassified pathogen: genomic and epidemiological features ofMicrobial genomics · 2026Article
- Population structure and phylogenetic analysis of Vibrio cholerae non-O1/O139 by whole genome sequencing.PloS one · 2026Article
- Genomic Analysis and Virulence Features of Vibrio cholerae Non-O1/Non-O139 Harbouring CARB-Type β-Lactamases From Freshwater Bodies, Argentina.Environmental microbiology reports · 2025Article
- Vibrio cholerae endemic to the lower Rio Grande Delta segregate into urban and rural phylotypes.Scientific reports · 2025Article
- Exploring Mobile Genetic Elements in Vibrio cholerae.Genome biology and evolution · 2025Article
- Non-O1/O139 environmental Vibrio cholerae from Northern Cameroon reveals potential intra-/inter-continental transmissions.PLoS neglected tropical diseases · 2025Article
- 'Wild Type'.Microbiology (Reading, England) · 2024Review
- Genome analysis of Streptococcus spp. isolates from animals in pre-antibiotic era with respect to antibiotic susceptibility and virulence gene profiles.Veterinary research · 2024Article
- Valid and accepted novel bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2022.Journal of clinical microbiology · 2023Review
- Plasmid-encoded lactose metabolism and mobilized colistin resistance (Microbial genomics · 2023Article
- Identification ofAntibiotics (Basel, Switzerland) · 2023Article
- NCTC3000: a century of bacterial strain collecting leads to a rich genomic data resource.Microbial genomics · 2023Article
- Population Analysis of Vibrio cholerae in Aquatic Reservoirs Reveals a Novel Sister Species (Applied and environmental microbiology · 2021Article
- Article
- Pan-Genome Analysis ofFrontiers in veterinary science · 2021Article
- Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae.Nature communications · 2020Article
- Vibrios from the Norwegian marine environment: Characterization of associated antibiotic resistance and virulence genes.MicrobiologyOpen · 2020Article
- 'Community evolution' - laboratory strains and pedigrees in the age of genomics.Microbiology (Reading, England) · 2020Article
- Looking Backward To Move Forward: the Utility of Sequencing Historical Bacterial Genomes.Journal of clinical microbiology · 2019Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The sixth global cholera pandemic lasted from 1899 to 1923. However, despite widespread fear of the disease and of its negative effects on troop morale, very few soldiers in the British Expeditionary Forces contracted cholera between 1914 and 1918. Here, we have revived and sequenced the genome of NCTC 30, a 102-year-old Vibrio cholerae isolate, which we believe is the oldest publicly available live V. cholerae strain in existence. NCTC 30 was isolated in 1916 from a British soldier convalescent in Egypt. We found that this strain does not encode cholera toxin, thought to be necessary to cause cholera, and is not part of V. cholerae lineages responsible for the pandemic disease. We also show that NCTC 30, which predates the introduction of penicillin-based antibiotics, harbours a functional β-lactamase antibiotic resistance gene. Our data corroborate and provide molecular explanations for previous phenotypic studies of NCTC 30 and provide a new high-quality genome sequence for historical, non-pandemic V. cholerae.
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