ArticleProceedings. Biological sciences2019
Lethal and sublethal synergistic effects of a new systemic pesticide, flupyradifurone (Sivanto
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 159 citations in OpenAlex.
- Protective effects of rosmarinic acid against carbaryl-exposed toxicity in honey bees (Apis mellifera): histopathological and molecular docking evidence.Veterinary research communications · 2026Article
- Carbohydrate limitation, but not exposure to the insecticide flupyradifurone, impairs wild bumblebee nest initiation.Environmental entomology · 2026Article
- Ubiquitous presence of pesticides in feathers of common UK birds.Environmental science and pollution research international · 2026Article
- What's in a pollen provision? Using larval provisions to quantify pesticide exposure in Megachile rotundata (Hymenoptera: Megachilidae).Environmental entomology · 2026Article
- Article
- Fluopyram in agricultural ecosystems: environmental fate, microbial transformation, ecotoxicity, and resistance risks of an SDHI fungicide.Frontiers in microbiology · 2026Review
- Article
- Synergistic effect of the next generation insecticide flupyradifurone with a fungal pathogen in the ant Lasius niger.Scientific reports · 2025Article
- The Sublethal Effects of Neonicotinoids on Honeybees.Biology · 2025Review
- Binary Mixture of Neonicotinoid-Pyrethroid Insecticide: Impact on Survival, Cognitive Learning, and Memory inBiology · 2025Article
- Bumblebees under stress: Interacting effects of pesticides and heatwaves on colony development and longevity.iScience · 2024Article
- Impact of copper and zinc oral chronic exposure on Carniolan honey bee survival and feeding preference.Journal of economic entomology · 2024Article
- Managing Microbiota Activity ofMicroorganisms · 2024Article
- Current Insights into Sublethal Effects of Pesticides on Insects.International journal of molecular sciences · 2024Review
- A novel insecticide impairs bumblebee memory and sucrose responsiveness across high and low nutrition.Royal Society open science · 2024Article
- Single and combined exposure to 'bee safe' pesticides alter behaviour and offspring production in a ground-nesting solitary bee (Proceedings. Biological sciences · 2024Article
- Interaction of Flupyradifurone and Deltamethrin, Two Pesticides Commonly Used for Plant Pest Control, in Honeybees.Animals : an open access journal from MDPI · 2024Article
- Bergamot Polyphenolic Fraction for the Control of Flupyradifurone-Induced Poisoning in Honeybees.Animals : an open access journal from MDPI · 2024Article
- Protective Role of Bergamot Polyphenolic Fraction (BPF) against Deltamethrin Toxicity in Honeybees (Animals : an open access journal from MDPI · 2023Article
- Influence of the pesticide flupyradifurone on mobility and physical condition of larval green lacewings.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The honeybee ( Apis mellifera L.) is an important pollinator and a model for pesticide effects on insect pollinators. The effects of agricultural pesticides on honeybee health have therefore raised concern. Bees can be exposed to multiple pesticides that may interact synergistically, amplifying their side effects. Attention has focused on neonicotinoid pesticides, but flupyradifurone (FPF) is a novel butenolide insecticide that is also systemic and a nicotinic acetylcholine receptor (nAChR) agonist. We therefore tested the lethal and sublethal toxic effects of FPF over different seasons and worker types, and the interaction of FPF with a common SBI fungicide, propiconazole. We provide the first demonstration of adverse synergistic effects on bee survival and behaviour (poor coordination, hyperactivity, apathy) even at FPF field-realistic doses (worst-case scenarios). Pesticide effects were significantly influenced by worker type and season. Foragers were consistently more susceptible to the pesticides (4-fold greater effect) than in-hive bees, and both worker types were more strongly affected by FPF in summer as compared with spring. Because risk assessment (RA) requires relatively limited tests that only marginally address bee behaviour and do not consider the influence of bee age and season, our results raise concerns about the safety of approved pesticides, including FPF. We suggest that pesticide RA also test for common chemical mixture synergies on behaviour and survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.