ArticleJournal of the Royal Society, Interface2019
Non-equilibrium landscape and flux reveal how the central amygdala circuit gates passive and active defensive responses.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Central amygdalaNeurobiology of stress · 2026Article
- Neural circuit mechanisms underlying dominance traits and social competition.Biophysics reviews · 2025Article
- Neural mechanisms balancing accuracy and flexibility in working memory and decision tasks.NPJ systems biology and applications · 2025Article
- Unraveling the Complexity of Parkinson's Disease: Insights into Pathogenesis and Precision Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Quantifying cancer cell plasticity with gene regulatory networks and single-cell dynamics.Frontiers in network physiology · 2023Review
- Metastable dynamics of neural circuits and networks.Applied physics reviews · 2022Review
- Perspectives on the landscape and flux theory for describing emergent behaviors of the biological systems.Journal of biological physics · 2022Review
- Visualization of subdiffusive sites in a live single cell.Journal of biological methods · 2021Article
- Non-equilibrium landscape and flux reveal the stability-flexibility-energy tradeoff in working memory.PLoS computational biology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Uncovering the underlying physical principles of biology is important for understanding the biological function yet challenging. Take an example, the animals' defensive systems are very effective to threats. However, the underlying physical mechanisms are still unclear. We developed a non-equilibrium physics framework in terms of landscape and flux to study a central lateral amygdala (CeL) neural circuit based on experimental findings. We show that the distinct active and passive defensive responses of the animals upon threats are a result of non-equilibrium phase transitions. Such non-equilibrium phase transitions result from thermodynamic symmetry breaking, which is induced dynamically by the non-equilibrium flux. This gives rise to the emergence and selection of passive and active fear defensive responses, which can be quantified by the changes on the topography of the underlying non-equilibrium landscape. We have found the strengthened synaptic transmissions to both the SOM
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Registered trials
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