Evidence map›Paper›PMID 30966948›Full record

ArticleJournal of the Royal Society, Interface2019

Adhesive-based tendon-to-bone repair: failure modelling and materials selection.

Evangelos I Avgoulas, Michael P F Sutcliffe, Stephen W Linderman, Victor Birman, Stavros Thomopoulos, Guy M Genin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Bioactive elements manipulate bone regeneration.Biomaterials translational · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Boost Tendon/Ligament Repair With Biomimetic and Smart Cellular Constructs.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Evangelos I Avgoulas1 Department of Engineering, University of Cambridge , Trumpington Street, Cambridge CB2 1PZ , UK.
Michael P F Sutcliffe1 Department of Engineering, University of Cambridge , Trumpington Street, Cambridge CB2 1PZ , UK.
Stephen W Linderman2 Department of Orthopaedic Surgery, Washington University School of Medicine , St Louis, MO 63131 , USA.
Victor Birman3 Missouri Science and Technology Global-St Louis, and Department of Mechanical and Aerospace Engineering , St Louis, MO 63131 , USA.
Stavros Thomopoulos4 Department of Orthopedic Surgery, Columbia University , New York, NY 10032 , USA.
Guy M Genin6 NSF Science and Technology Center for Engineering Mechanobiology, Department of Mechanical and Aerospace Engineering, Washington University , St Louis, MO 63130 , USA.
University of Cambridge · GBWashington University in St. Louis · USColumbia University · US

Funding

Enhanced Tendon Healing Through Growth Factor and Cell TherapiesR01AR062947 · NIAMS · WASHINGTON UNIVERSITY · PI GELBERMAN, RICHARD H, THOMOPOULOS, STAVROS · 2012 to 2022
$5.5M
Skeletal Disorders Training ProgramT32AR060719 · NIAMS · WASHINGTON UNIVERSITY · PI Roberto Civitelli · 2011 to 2026
$4.6M
Cross-scale interactions between mineral and collagen for tendon-bone attachmentU01EB016422 · NIBIB · WASHINGTON UNIVERSITY · PI GENIN, GUY M, THOMOPOULOS, STAVROS · 2013 to 2017
$2.4M
Improved orthopaedic repairs through mechanically optimized, adhesive biomaterialsF30AR069491 · NIAMS · WASHINGTON UNIVERSITY · PI LINDERMAN, STEPHEN W · 2016 to 2018
$140k
NIAMS NIH HHS F30 AR069491NIAMS NIH HHS R01 AR062947NIAMS NIH HHS T32 AR060719NIBIB NIH HHS U01 EB016422
6 · The paper itself

Abstract

Surgical reattachment of tendon to bone is a procedure marked by high failure rates. For example, nearly all rotator cuff repairs performed on elderly patients with massive tears ultimately result in recurrence of tearing. These high failure rates have been attributed to stress concentrations that arise due to the mechanical mismatch between tendon and bone. Although recent studies have identified potential adhesives with mechanical properties tuned to alleviate these stress concentrations, and thereby delay the onset of failure, resistance to the progression of failure has not been studied. Here, we refined the space of adhesive material properties that can improve surgical attachment by considering the fracture process. Using cohesive zone modelling and physiologically relevant values of mode I and mode II adhesive fracture toughnesses, we predicted the maximum displacement and strength at failure of idealized, adhesively bonded tendon-to-bone repairs. Repair failure occurred due to excessive relative displacement of the tendon and bone tissues for strong and compliant adhesives. The failure mechanism shifted to rupture of the entire repair for stiffer adhesives below a critical shear strength. Results identified a narrow range of materials on an Ashby chart that are suitable for adhesive repair of tendon to bone, including a range of elastomers and porous solids.

Indexed as

AdhesivesBiocompatible MaterialsAnimalsBiomechanical PhenomenaBone and BonesHumansModels, BiologicalStress, MechanicalTendon InjuriesTendonsWound HealingAdhesivesBiocompatible Materialscohesive zone modelenthesisrotator cuff

Identifiers

PMID30966948
PMCPMC6505561
OpenAlexW2939450274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.