ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Non-genetic inheritance via the male germline in mammals.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Signatures of metabolic diseases on spermatogenesis and testicular metabolism.Nature reviews. Urology · 2024Review
- Grandchildren's Longevity and Their Grandfathers' POW Trauma in the U.S. Civil War.Demography · 2024Article
- Overweight grandsons and grandfathers' starvation exposure.Journal of health economics · 2023Article
- Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring.Biochemistry and biophysics reports · 2022Article
- Metabolic Consequences of Glucocorticoid Exposure before Birth.Nutrients · 2022Review
- Testicular "Inherited Metabolic Memory" of Ancestral High-Fat Diet Is Associated with Sperm sncRNA Content.Biomedicines · 2022Article
- Dynamic and Systemic Perspective in Autism Spectrum Disorders: A Change of Gaze in Research Opens to A New Landscape of Needs and Solutions.Brain sciences · 2022Review
- Human transgenerational observations of regular smoking before puberty on fat mass in grandchildren and great-grandchildren.Scientific reports · 2022Article
- The potential role of stress and sex steroids in heritable effects of sevoflurane†.Biology of reproduction · 2021Review
- Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in mice.Scientific reports · 2021Article
- Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects.Frontiers in endocrinology · 2021Review
- Desmosterol Incorporation Into Ram Sperm Membrane Before Cryopreservation ImprovesFrontiers in cell and developmental biology · 2021Article
- Epigenetic variation in animal populations: Sources, extent, phenotypic implications, and ecological and evolutionary relevance.Journal of biosciences · 2021Review
- Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences.Early human development · 2020Review
- The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis.Clinical epigenetics · 2020Article
- The Intergenerational Impacts of Paternal Diet on DNA Methylation and Offspring Phenotypes in Sheep.Frontiers in genetics · 2020Article
- Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health.Environmental epigenetics · 2020Review
- The Ancestral Environment Shapes Antiviral CD8iScience · 2019Article
- Stress resilience in young men mediates the effect of childhood trauma on their offspring's birth weight - An analysis of 250,000 families.SSM - population health · 2019Article
- Developing differences: early-life effects and evolutionary medicine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Numerous studies in humans and in animal models have demonstrated that exposure to adverse environmental conditions in early life results in long-term structural and functional changes in an organism, increasing the risk of cardiometabolic, neurobehavioural and reproductive disorders in later life. Such effects are not limited to the first generation offspring but may be transmitted to a second or a number of subsequent generations, through non-genomic mechanisms. While the transmission of 'programmed' effects through the maternal line could occur as a consequence of multiple influences, for example, altered maternal physiology, the inheritance of effects through the male line is more difficult to explain and there is much interest in a potential role for transgenerational epigenetic inheritance. In this review, we will discuss the mechanisms by which induced effects may be transmitted through the paternal lineage, with a particular focus on the role of epigenetic inheritance. This article is part of the theme issue 'Developing differences: early-life effects and evolutionary medicine'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.