ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Early-life manipulation of cortisol and its receptor alters stress axis programming and social competence.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Maternal glucocorticoids have persistent effects on offspring social phenotype irrespective of opportunity for social buffering.The Journal of animal ecology · 2026Article
- Early life adversity shapes adult behavior in a free-ranging primate.bioRxiv : the preprint server for biology · 2026Article
- Sibling number and early interactions shape social competence for life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Flexibility in task performance and division of labour in a cooperatively breeding cichlid.Behavioral ecology and sociobiology · 2026Article
- Social fish have larger brains and greater relative telencephalon sizes: support for the social brain hypothesis from wild, intraspecific comparisons.Proceedings. Biological sciences · 2025Article
- Rainbow Trout (International journal of molecular sciences · 2025Article
- Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor.Biomedicines · 2024Article
- Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload.The Journal of experimental biology · 2024Review
- Stress in the social context: a behavioural and eco-evolutionary perspective.The Journal of experimental biology · 2023Review
- Developmental Programming by Perinatal Glucocorticoids.Molecules and cells · 2022Review
- Article
- Stress axis programming generates long-term effects on cognitive abilities in a cooperative breeder.Proceedings. Biological sciences · 2022Article
- Predator-induced maternal effects determine adaptive antipredator behaviors via egg composition.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Early social deprivation shapes neuronal programming of the social decision-making network in a cooperatively breeding fish.Molecular ecology · 2021Article
- Early-life stress influences ion balance in developing zebrafish (Danio rerio).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Chronic unpredictable stress induces anxiety-like behaviors in young zebrafish.Scientific reports · 2020Article
- Article
- Implication of Spiritual Network Support System in Epigenomic Modulation and Health Trajectory.International journal of environmental research and public health · 2019Review
- Developing differences: early-life effects and evolutionary medicine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many vertebrate species, early social experience generates long-term effects on later life social behaviour. These effects are accompanied by persistent modifications in the expression of genes implicated in the stress axis. It is unknown, however, whether stress axis programming can affect the development of social competence, and if so, by which mechanism(s). Here, we used pharmacological manipulations to persistently reprogramme the hypothalamic-pituitary-interrenal axis of juvenile cooperatively breeding cichlids, Neolamprologus pulcher. During the first two months of life, juveniles were repeatedly treated with cortisol, mifepristone or control treatments. Three months after the last manipulation, we tested for treatment effects on (i) social competence, (ii) the expression of genes coding for corticotropin-releasing factor ( crf), glucocorticoid receptor ( gr1) and mineralocorticoid receptor ( mr) in the telencephalon and hypothalamus and (iii) cortisol levels. Social competence in a social challenge was reduced in cortisol-treated juveniles, which is in accordance with previous work applying early-life manipulations using different social experiences. During early life, both cortisol and mifepristone treatments induced a persistent downregulation of crf and upregulation of mr in the telencephalon. We suggest that these persistent changes in stress gene expression may represent an effective physiological mechanism for coping with stress. This article is part of the theme issue 'Developing differences: early-life effects and evolutionary medicine'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.