Evidence map›Paper›PMID 30966670›Full record

ArticlePolymers2018

Inhalable Fucoidan Microparticles Combining Two Antitubercular Drugs with Potential Application in Pulmonary Tuberculosis Therapy.

Ludmylla Cunha, Susana Rodrigues, Ana M Rosa da Costa, M Leonor Faleiro, Francesca Buttini, Ana Grenha

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  10. Article
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  12. The effect of ethanol on the habit andAsian journal of pharmaceutical sciences · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Hydrothermal Processing ofMarine drugs · 2020
    Article
  17. Article
  18. Article
  19. Multifunctional Nanocarriers for Lung Drug Delivery.Nanomaterials (Basel, Switzerland) · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ludmylla CunhaCentre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal. ludmyllacc@gmail.com.
Susana RodriguesCentre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal. susananasus@gmail.com.ORCID 0000-0002-0329-4265
Ana M Rosa da CostaAlgarve Chemistry Research Centre and Department of Chemistry and Pharmacy, University of Algarve, 8005-139 Faro, Portugal. amcosta@ualg.pt.ORCID 0000-0003-0225-9537
M Leonor FaleiroCentre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal. mfaleiro@ualg.pt.
Francesca ButtiniFood and Drug Department, University of Parma, 43124 Parma, Italy. francesca.buttini@unipr.it.
Ana GrenhaCentre for Biomedical Research, University of Algarve, 8005-139 Faro, Portugal. amgrenha@ualg.pt.ORCID 0000-0002-2136-1396
University of Algarve · PTUniversity of Parma · IT

Funding

CANCER AND LEUKEMIA GROUP B (CALGB)U10CA004326 · NCI · DARTMOUTH COLLEGE · PI ERNSTOFF, MARC S · 1985 to 2002
$546k
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior BEX 1168/13-4Fundação para a Ciência e a Tecnologia PTDC/DTP-FTO/0094/2012Fundação para a Ciência e a Tecnologia UID/BIM/04773/2013Fundação para a Ciência e a Tecnologia UID/Multi/04326/2013
6 · The paper itself

Abstract

The pulmonary delivery of antitubercular drugs is a promising approach to treat lung tuberculosis. This strategy not only allows targeting the infected organ instantly, it can also reduce the systemic adverse effects of the antibiotics. In light of that, this work aimed at producing fucoidan-based inhalable microparticles that are able to associate a combination of two first-line antitubercular drugs in a single formulation. Fucoidan is a polysaccharide composed of chemical units that have been reported to be specifically recognised by alveolar macrophages (the hosts of

Indexed as

alveolar macrophagesfucoidaninhalable microparticlesisoniazidrifabutinspray-dryingtuberculosis therapy

Identifiers

PMID30966670
PMCPMC6403622
OpenAlexW2807135312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.