Evidence map›Paper›PMID 30966641›Full record

ArticlePolymers2018

Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives.

Andreea-Teodora Iacob, Maria Drăgan, Nicolae Ghețu, Dragoș Pieptu, Cornelia Vasile, Frédéric Buron, Sylvain Routier, Simona Elena Giusca, Irina-Draga Caruntu, Lenuța Profire

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Versatile Use of Chitosan and Hyaluronan in Medicine.Molecules (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Andreea-Teodora IacobDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania. lenuta.profire@umfiasi.ro.
Maria DrăganDepartment of Pharmaceutical Biotechnologies and Drug Industry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania. mwolszleger@yahoo.com.
Nicolae GhețuDepartment of Plastic Surgery, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania. ghetu.nicolae@umfiasi.ro.
Dragoș PieptuDepartment of Plastic Surgery, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania. dragos.pieptu@umfiasi.ro.ORCID 0000-0001-8742-7581
Cornelia VasileDepartment of Physical Chemistry of Polymers, "Petru Poni" Institute of Macromolecular Chemistry, 41A Grigore GhicaVoda Alley, Iasi 700487, Romania. cvasile@icmpp.ro.ORCID 0000-0003-1854-0278
Frédéric BuronInstitut de Chimie Organique et Analytique (ICOA), Univ Orleans, UMR CNRS 7311, F-45067 Orléans, France. frederic.buron@univ-orleans.fr.ORCID 0000-0001-5773-1515
Sylvain RoutierInstitut de Chimie Organique et Analytique (ICOA), Univ Orleans, UMR CNRS 7311, F-45067 Orléans, France. sylvain.routier@univ-orleans.fr.
Simona Elena GiuscaDepartment of Morphofunctional Sciences, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania. simona-eliza.giusca@umfiasi.ro.
Irina-Draga CaruntuDepartment of Morphofunctional Sciences, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania. irina.caruntu@umfiasi.ro.
Lenuța ProfireDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania. lenuta.profire@umfiasi.ro.
Grigore T. Popa University of Medicine and Pharmacy · ROCentre National de la Recherche Scientifique · FR

Funding

Romanian National Authority for Scientific Research, CNCS-UEFISCDI PN-II-ID-PCE-2011-3-0906 and PN-III-P2-2.1-2016-1807 (151 PED/2017)
6 · The paper itself

Abstract

New membranes based on chitosan and chitosan-hyaluronic acid containing new arginine derivatives with thiazolidine-4-one scaffold have been prepared using the ionic cross-linking method. The presence of the arginine derivatives with thiazolidine-4-one scaffold into the polymer matrix was proved by Fourier-transform infrared spectroscopy (FT-IR). The scanning electron microscopy (SEM) revealed a micro-porous structure that is an important characteristic for the treatment of burns, favoring the exudate absorption, the rate of colonization, the cell structure, and the angiogenesis process. The developed polymeric membranes also showed good swelling degree, improved hydrophilicity, and biocompatibility in terms of surface free energy components, which supports their application for tissue regeneration. Moreover, the chitosan-arginine derivatives (CS-6h, CS-6i) and chitosan-hyaluronic acid-arginine derivative (CS-HA-6h) membranes showed good healing effects on the burn wound model induced to rats. For these membranes a complete reepithelialization was observed after 15 days of the experiment, which supports a faster healing process.

Indexed as

arginine derivativeschitosanhyaluronic acidwound dressing

Identifiers

PMID30966641
PMCPMC6404145
OpenAlexW2806958406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.