ArticlePolymers2018
Novel Bacterial Cellulose/Gelatin Hydrogels as 3D Scaffolds for Tumor Cell Culture.
Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- Core-Shell Biocompatible Piezoelectric Nanocomposite with Enhanced Cell Adhesion for Potential Biomedical Applications.ACS omega · 2026Article
- In Vitro Biodegradation and Biocompatibility of Bacterial Nanocellulose-Chitosan-Based Hydrogel Scaffolds for Bone Tissue Engineering.ACS omega · 2025Article
- Nano-Engineered Hybridized Polymeric Framework for Chronic Wound Management.AAPS PharmSciTech · 2025Article
- Innovation in ovary decellularization methods: Chemical and herbal detergents.Regenerative therapy · 2025Article
- Highly Flexible Methyl Cellulose/Gelatin Hydrogels for Potential Cartilage Tissue Engineering Applications.Biopolymers · 2025Article
- Development of a bacterial cellulose-gelatin composite as a suitable scaffold for cardiac tissue engineering.Biotechnology letters · 2024Article
- Review
- Decellularized kidney capsule as a three-dimensional scaffold for tissue regeneration.Cell and tissue banking · 2024Article
- The Decellularized Calf Testis: Introducing Suitable Scaffolds for Spermatogenesis Studies.International journal of fertility & sterility · 2023Article
- Polysaccharides and Structural Proteins as Components in Three-Dimensional Scaffolds for Breast Cancer Tissue Models: A Review.Bioengineering (Basel, Switzerland) · 2023Review
- Cassava microfiber-reinforced gelatin scaffold holds promise for tissue engineering by exhibiting cytocompatibility with HEK 293 cells.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Effect of Composition and Freeze-Thaw on the Network Structure, Porosity and Mechanical Properties of Polyvinyl-Alcohol/Chitosan Hydrogels.Gels (Basel, Switzerland) · 2023Article
- Bacterial Cellulose-Based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications.International journal of molecular sciences · 2023Review
- Bacterial Cellulose Cultivations Containing Gelatin Form Tunable, Highly Ordered, Laminae Structures with Fourfold Enhanced Productivity.ACS omega · 2022Article
- Multiple Cell Cultures for MRI Analysis.International journal of molecular sciences · 2022Review
- Nucleoside-Derived Low-Molecular-Weight Gelators as a Synthetic Microenvironment for 3D Cell Culture.ACS biomaterials science & engineering · 2022Article
- Polymeric Hydrogels for In Vitro 3D Ovarian Cancer Modeling.International journal of molecular sciences · 2022Review
- A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting.Materials (Basel, Switzerland) · 2021Review
- Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review.International journal of environmental research and public health · 2020Review
- Expanding sacrificially printed microfluidic channel-embedded paper devices for construction of volumetric tissue models in vitro.Biofabrication · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Three-dimensional (3D) cells in vitro culture are becoming increasingly popular in cancer research because some important signals are lost when cells are cultured in a two-dimensional (2D) substrate. In this work, bacterial cellulose (BC)/gelatin hydrogels were successfully synthesized and were investigated as scaffolds for cancer cells in vitro culture to simulate tumor microenvironment. Their properties and ability to support normal growth of cancer cells were evaluated. In particular, the human breast cancer cell line (MDA-MD-231) was seeded into BC/gelatin scaffolds to investigate their potential in 3D cell in vitro culture. MTT proliferation assay, scanning electron microscopy, hematoxylin and eosin staining and immunofluorescence were used to determine cell proliferation, morphology, adhesion, infiltration, and receptor expression. The in vitro MDA-MD-231 cell culture results demonstrated that cells cultured on the BC/gelatin scaffolds had significant adhesion, proliferation, ingrowth and differentiation. More importantly, MDA-MD-231 cells cultured in BC/gelatin scaffolds retained triple-negative receptor expression, demonstrating that BC/gelatin scaffolds could be used as ideal in vitro culture scaffolds for tumor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.