ArticlePolymers2018
3D Printing of Thermoresponsive Polyisocyanide (PIC) Hydrogels as Bioink and Fugitive Material for Tissue Engineering.
Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hydrogels for Bioprinting: A Systematic Review of Hydrogels Synthesis, Bioprinting Parameters, and Bioprinted Structures Behavior.Frontiers in bioengineering and biotechnology · 2020Pooled it
- Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Multiscale Construction, Evaluation, and Application of Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The Use of Additive Manufacturing Techniques in the Development of Polymeric Molds: A Review.Polymers · 2024Review
- Perfusable Tissue Bioprinted into a 3D-Printed Tailored Bioreactor System.Bioengineering (Basel, Switzerland) · 2024Article
- Thermoresponsive Alginate-Graft-pNIPAM/Methyl Cellulose 3D-Printed Scaffolds Promote Osteogenesis In Vitro.Gels (Basel, Switzerland) · 2023Article
- Cell-matrix reciprocity in 3D culture models with nonlinear elasticity.Bioactive materials · 2022Review
- Hybrid 3D Printing of Advanced Hydrogel-Based Wound Dressings with Tailorable Properties.Pharmaceutics · 2021Article
- A Chemically Defined Hydrogel for Human Liver Organoid Culture.Advanced functional materials · 2020Article
- Crosslinking Strategies for 3D Bioprinting of Polymeric Hydrogels.Small (Weinheim an der Bergstrasse, Germany) · 2020Review
- From Shape to Function: The Next Step in Bioprinting.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- Hydrogels for Liver Tissue Engineering.Bioengineering (Basel, Switzerland) · 2019Review
- 3D Bioprinting in Skeletal Muscle Tissue Engineering.Small (Weinheim an der Bergstrasse, Germany) · 2019Review
- Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating.Biomacromolecules · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Despite the rapid and great developments in the field of 3D hydrogel printing, a major ongoing challenge is represented by the development of new processable materials that can be effectively used for bioink formulation. In this work, we present an approach to 3D deposit, a new class of fully-synthetic, biocompatible PolyIsoCyanide (PIC) hydrogels that exhibit a reverse gelation temperature close to physiological conditions (37 °C). Being fully-synthetic, PIC hydrogels are particularly attractive for tissue engineering, as their properties-such as hydrogel stiffness, polymer solubility, and gelation kinetics-can be precisely tailored according to process requirements. Here, for the first time, we demonstrate the feasibility of both 3D printing PIC hydrogels and of creating dual PIC-Gelatin MethAcrylate (GelMA) hydrogel systems. Furthermore, we propose the use of PIC as fugitive hydrogel to template structures within GelMA hydrogels. The presented approach represents a robust and valid alternative to other commercial thermosensitive systems-such as those based on Pluronic F127-for the fabrication of 3D hydrogels through additive manufacturing technologies to be used as advanced platforms in tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.