Evidence map›Paper›PMID 30966553›Full record

ArticlePolymers2018

PLGA Microspheres Loaded with β-Cyclodextrin Complexes of Epigallocatechin-3-Gallate for the Anti-Inflammatory Properties in Activated Microglial Cells.

Chun-Yuan Cheng, Quoc-Hue Pho, Xiao-Yu Wu, Ting-Yu Chin, Chien-Min Chen, Peng-Hsiang Fang, Yung-Chang Lin, Ming-Fa Hsieh

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chun-Yuan ChengDivision of Neurosurgery, Department of Surgery, Changhua Christian Hospital, 135 Nanxiao St., Changhua City, Changhua County 500, Taiwan. 83998@cch.org.tw.
Quoc-Hue PhoDepartment of Biomedical Engineering, Chung Yuan Christian University, 200 Chung-Pei Rd., Chung Li District, Taoyuan City 32023, Taiwan. phoquochue@gmail.com.ORCID 0000-0002-2711-2227
Xiao-Yu WuDepartment of Biomedical Engineering, Chung Yuan Christian University, 200 Chung-Pei Rd., Chung Li District, Taoyuan City 32023, Taiwan. venus801206@gmail.com.
Ting-Yu ChinDepartment of Bioscience Technology, Chung Yuan Christian University, 200 Chung-Pei Rd., Chung Li District, Taoyuan City 32023, Taiwan. tychin@cycu.edu.tw.
Chien-Min ChenDivision of Neurosurgery, Department of Surgery, Changhua Christian Hospital, 135 Nanxiao St., Changhua City, Changhua County 500, Taiwan. 96015@cch.org.tw.
Peng-Hsiang FangDivision of Neurosurgery, Department of Surgery, Yuanlin Christian Hospital, No.456, Juguang Rd., Yuanlin City, Changhua County 510, Taiwan. doctorcombine@gmail.com.
Yung-Chang LinDepartment of Veterinary Medicine, National Chung Hsing University, 145 Xingda Rd., South District, Taichung City 402, Taiwan. ylin@email.nchu.edu.tw.
Ming-Fa HsiehDepartment of Biomedical Engineering, Chung Yuan Christian University, 200 Chung-Pei Rd., Chung Li District, Taoyuan City 32023, Taiwan. mfhsieh@cycu.edu.tw.ORCID 0000-0001-5254-1341
Chung Yuan Christian University · TWChanghua Christian Hospital · TWNational Chung Hsing University · TW

Funding

Changhua Christian Hospital, TaiwanMinistry of Science and Technology, Taiwan MOST-102-2632-M-033-001-MY3, MOST-106-2221-E-033-016
6 · The paper itself

Abstract

Although epigallocatechin-3-gallate (EG) is well-known as a potent antioxidant and free radical scavenger for neurodegenerative diseases, it still has disadvantages that reduce its treatment effectiveness due to low bioavailability, slow absorption, and water solubility. Therefore, the aim of this study is to improve the bioavailability of EG and increase the effectiveness of anti-inflammatory properties to microglial cells by using Poly(Lactide-

Indexed as

anti-inflammationbiodegradablebovine serum albuminepigallocatechin-3-gallatemicroglia cellsnon-toxicityPLGAβ-cyclodextrin

Identifiers

PMID30966553
PMCPMC6415370
OpenAlexW2802499308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.