ArticlePolymers2018
A Facile, One-Pot, Surfactant-Free Nanoprecipitation Method for the Preparation of Nanogels from Polyglycerol⁻Drug Conjugates that Can Be Freely Assembled for Combination Therapy Applications.
Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The effect of spacers in dual drug-polymer conjugates toward combination therapeutic efficacy.Scientific reports · 2021Article
- Synthesis Characterization of Platinum (IV) Complex Curcumin Backboned Polyprodrugs: In Vitro Drug Release Anticancer Activity.Polymers · 2020Article
- Mannose-Decorated Dendritic Polyglycerol Nanocarriers Drive Antiparasitic Drugs ToPharmaceutics · 2020Article
- Microflow Nanoprecipitation of Positively Charged Gastroresistant Polymer Nanoparticles of EudragitMaterials (Basel, Switzerland) · 2020Article
- Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model.Theranostics · 2020Article
- Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy.Polymers · 2018Article
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Authors and funding
3 authors.
Funding
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Abstract
A well-established strategy to treat drug resistance is the use of multiple therapeutics. Polymer-based drug delivery systems (DDS) can facilitate a simultaneous delivery of two or more drugs. In this study, we developed and synthesized a dendritic polyglycerol (PG) nanogel (NG) system that allows for free combination of different fixed ratios of active compound conjugates within a single NG particle. As a proof of concept, we synthesized NGs bearing the chemotherapeutic agent doxorubicin (DOX) and paclitaxel (PTX) in different ratios, as well as conjugated dye molecules. Our combination PG NGs were formed by simply mixing PG⁻drug/dye conjugates bearing free thiol groups with PG-acrylate in an inverse surfactant-free nanoprecipitation method. With this method we obtained PG-NGs in the size range of 110⁻165 nm with low polydispersity indices. Solubility of hydrophobic PTX was improved without the need for additional solubilizing agents such as polyethylene glycol (PEG). Interestingly, we found that our NGs made from PG-DOX conjugates have a high quenching efficiency for DOX, which could be interesting for theranostic purposes.
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