ArticlePolymers2018
ECM Decorated Electrospun Nanofiber for Improving Bone Tissue Regeneration.
Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Enhanced Cell Proliferation, Migration, and Fibroblast Differentiation with Electrospun PCL-Zinc Scaffolds Coated with Fibroblast-Derived ECM.ACS omega · 2025Article
- From electricity to vitality: the emerging use of piezoelectric materials in tissue regeneration.Burns & trauma · 2024Review
- Nanofibers: A current era in drug delivery system.Heliyon · 2023Review
- A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis.Bioactive materials · 2023Article
- Celery-derived scaffolds with liver lobule-mimicking structures for tissue engineering transplantation.Smart medicine · 2022Article
- Review
- Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications.Polymers · 2022Review
- BMSCs and Osteoblast-Engineered ECM Synergetically Promotes Osteogenesis and Angiogenesis in an Ectopic Bone Formation Model.Frontiers in bioengineering and biotechnology · 2022Article
- Fibrous Polymer-Based Composites Obtained by Electrospinning for Bone Tissue Engineering.Polymers · 2021Review
- Mechanical Stimulation and Diameter of Fiber Scaffolds Affect the Differentiation of Rabbit Annulus Fibrous Stem Cells.Tissue engineering and regenerative medicine · 2021Article
- Review
- Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2020Review
- Polymeric nanofibrous scaffolds laden with cell-derived extracellular matrix for bone regeneration.Materials science & engineering. C, Materials for biological applications · 2020Article
- Recent advances in biomaterials for 3D scaffolds: A review.Bioactive materials · 2019Article
- Photoresponsive Delivery Microcarriers for Tissue Defects Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Co-culture cell-derived extracellular matrix loaded electrospun microfibrous scaffolds for bone tissue engineering.Materials science & engineering. C, Materials for biological applications · 2019Article
- Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications.Nanomaterials (Basel, Switzerland) · 2019Review
- A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering.Membranes · 2018Review
- Gelatin/Nanohyroxyapatite Cryogel Embedded Poly(lactic-Polymers · 2018Article
- Customizing the Protoscolicidal Activity by a Drug Delivery System: Application of Guar Gum in Electrospun Nanofibers.Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimization of nanofiber surface properties can lead to enhanced tissue regeneration outcomes in the context of bone tissue engineering. Herein, we developed a facile strategy to decorate elctrospun nanofibers using extracellular matrix (ECM) in order to improve their performance for bone tissue engineering. Electrospun PLLA nanofibers (PLLA NF) were seeded with MC3T3-E1 cells and allowed to grow for two weeks in order to harvest a layer of ECM on nanofiber surface. After decellularization, we found that ECM was successfully preserved on nanofiber surface while maintaining the nanostructure of electrospun fibers. ECM decorated on PLLA NF is biologically active, as evidenced by its ability to enhance mouse bone marrow stromal cells (mBMSCs) adhesion, support cell proliferation and promote early stage osteogenic differentiation of mBMSCs. Compared to PLLA NF without ECM, mBMSCs grown on ECM/PLLA NF exhibited a healthier morphology, faster proliferation profile, and more robust osteogenic differentiation. Therefore, our study suggests that ECM decoration on electrospun nanofibers could serve as an efficient approach to improving their performance for bone tissue engineering.
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Registered trials
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