Evidence map›Paper›PMID 30966177›Full record

ArticlePolymers2018

Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation.

Simone Beck, Jennifer Schultze, Hans-Joachim Räder, Regina Holm, Meike Schinnerer, Matthias Barz, Kaloian Koynov, Rudolf Zentel

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. Development of in situ crosslinked hyaluronan as an adjunct to vitrectomy surgery.Journal of materials science. Materials in medicine · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Simone BeckInstitute of Organic Chemistry, Johannes-Gutenberg University Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany. becksi@uni-mainz.de.
Jennifer SchultzeMax-Planck-Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany. schultze@mpip-mainz.mpg.de.
Hans-Joachim RäderMax-Planck-Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
Regina HolmInstitute of Organic Chemistry, Johannes-Gutenberg University Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany. rholm@uni-mainz.de.
Meike SchinnererInstitute of Physical Chemistry, Jakob Welder Weg 11, D-55128 Mainz, Germany. mschin@uni-mainz.de.
Matthias BarzInstitute of Organic Chemistry, Johannes-Gutenberg University Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany. barz@uni-mainz.de.ORCID 0000-0002-1749-9034
Kaloian KoynovMax-Planck-Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany. koynov@mpip-mainz.mpg.de.ORCID 0000-0002-4062-8834
Rudolf ZentelInstitute of Organic Chemistry, Johannes-Gutenberg University Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany. zentel@uni-mainz.de.ORCID 0000-0001-9206-6047
Johannes Gutenberg University Mainz · DEMax Planck Institute for Polymer Research · DEMax Planck Institute for Chemistry · DEUniversity of Applied Sciences Mainz · DE

Funding

Deutsche Forschungsgemeinschaft SFB1066
6 · The paper itself

Abstract

The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune system to combat tumour cells. In this work, we investigated the chemical attachment of DEC205 antibodies (aDEC205) as DC-targeting structures to polyplexes of P(Lys)-

Indexed as

bioorthogonal chemistrycancer immune therapyDEC205 antibodydendritic cells (DCs)pDNA polyplexRAFT polymerizationstrain-promoted alkyne-azide cycloaddition (SPAAC)targetingvaccination

Identifiers

PMID30966177
PMCPMC6414842
OpenAlexW2792025888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.