ArticlePolymers2017
Preparation and Characterization of Breathable Hemostatic Hydrogel Dressings and Determination of Their Effects on Full-Thickness Defects.
Article in Polymers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Hydrogels in the Management of Peripheral Venous Disease: Bridging Material Design and Clinical Evidence.Gels (Basel, Switzerland) · 2026Review
- Hemostatic and Wound Healing Nonisocyanate Polyhydroxyurethanes (NIPHUs) Dressings from Soybean Oil:ACS omega · 2026Article
- Preclinical Evaluation of a Chitosan-Based Field Hemostatic Sponge in Arterial Bleeding Models with and Without Aspirin Administration.Journal of functional biomaterials · 2026Article
- Article
- Fabrication of a visible light photocrosslinkable κ-carrageenan-gelatin hydrogel patch to aid in wound healing applications.Frontiers in bioengineering and biotechnology · 2026Article
- Self-healing PVA/PVP micelle-hydrogel composite system for potential phenytoin repositioning in wound healing.Journal of biological engineering · 2025Article
- A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications.Gels (Basel, Switzerland) · 2025Review
- Investigation of Silver- and Plant Extract-Infused Polymer Systems: Antioxidant Properties and Kinetic Release.International journal of molecular sciences · 2024Article
- Recent Advances in Poly(vinyl alcohol)-Based Hydrogels.Polymers · 2024Review
- Essential Oils as Antimicrobial Active Substances in Wound Dressings.Materials (Basel, Switzerland) · 2022Article
- Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care.Scientific reports · 2022Article
- Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications.Pharmaceutics · 2022Review
- Advances in the development and optimization strategies of the hemostatic biomaterials.Frontiers in bioengineering and biotechnology · 2022Review
- Marine Polysaccharides for Wound Dressings Application: An Overview.Pharmaceutics · 2021Review
- Preparation of Silk Fibroin/Carboxymethyl Chitosan Hydrogel under Low Voltage as a Wound Dressing.International journal of molecular sciences · 2021Article
- Evaluation of the Wound Healing Potential of Some Natural Polymers on Three Experimental Models.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Application and outlook of topical hemostatic materials: a narrative review.Annals of translational medicine · 2021Review
- Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss.Heliyon · 2021Article
- Polydopamine-Based Surface Modification of ZnO Nanoparticles on Sericin/Polyvinyl Alcohol Composite Film for Antibacterial Application.Molecules (Basel, Switzerland) · 2019Article
- Patterned Polyvinyl Alcohol Hydrogel Dressings with Stem Cells Seeded for Wound Healing.Polymers · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Hydrogel-based wound dressings provide a cooling sensation, a moist environment, and act as a barrier to microbes for wounds. In this study, a series of soft, flexible, porous non-stick hydrogel dressings were prepared through the simple repeated freeze-thawing of a poly(vinyl alcohol), human-like collagen (or and carboxymethyl chitosan) mixed solution rather than chemical cross-linking and Tween80 was added as pore-forming agent for cutaneous wound healing. Some of their physical and chemical properties were characterized. Interestingly, hydrogel PVA-HLC-T80 and PVA-HLC-CS-T80 presented excellent swelling ratios, bacterial barrier activity, moisture vapor permeability, hemostasis activity and biocompatibility. Furthermore, in vivo evaluation of the healing capacity of these two hydrogels was checked by creating a full-thickness wound defect (1.3 cm × 1.3 cm) in rabbit. Macroscopic observation and subsequent hematoxylin eosin staining (H&E) staining and transmission electron microscopy (TEM) analysis at regular time intervals for 18 days revealed that the hydrogels significantly enhanced wound healing by reducing inflammation, promoting granulation tissue formation, collagen deposition and accelerating re-epithelialization. Taken together, the obtained data strongly encourage the use of these multifunctional hydrogels for skin wound dressings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.