ArticlePolymers2017
In Vitro and in Vivo Study of Poly(Lactic⁻co⁻Glycolic) (PLGA) Membranes Treated with Oxygen Plasma and Coated with Nanostructured Hydroxyapatite Ultrathin Films for Guided Bone Regeneration Processes.
Article in Polymers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Influence of Treated Surface Proportion on the Antibacterial Performance of UV-Activated Hydroxyapatite-Magnesium Phosphate-Zinc Oxide Coating on Magnesium Alloys.Journal of functional biomaterials · 2026Article
- Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices.Pharmaceutics · 2024Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Elaboration and Biocompatibility of an Eggshell-Derived Hydroxyapatite Material Modified with Si/PLGA for Bone Regeneration in Dentistry.International journal of dentistry · 2019Article
- In Vitro Comparative Study of Oxygen Plasma Treated Poly(Lactic⁻Co⁻Glycolic) (PLGA) Membranes and Supported Nanostructured Oxides for Guided Bone Regeneration Processes.Materials (Basel, Switzerland) · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The novelty of this study is the addition of an ultrathin layer of nanostructured hydroxyapatite (HA) on oxygen plasma modified poly(lactic⁻
methodsTwo groups of regenerative membranes were prepared: PLGA (control) and PLGA/PO₂/HA (experimental). These membranes were subjected to cell cultures and then used to cover bone defects prepared on the skulls of eight experimental rabbits.
resultsCell morphology and adhesion of the osteoblasts to the membranes showed that the osteoblasts bound to PLGA were smaller and with a lower number of adhered cells than the osteoblasts bound to the PLGA/PO₂/HA membrane (
conclusionsThe incorporation of nanometric layers of nanostructured HA into PLGA membranes modified with PO₂ might be considered for the regeneration of bone defects. PLGA/PO₂/HA membranes promote higher osteosynthetic activity, new bone formation, and mineralisation than the PLGA control group.
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