ArticleMolecules (Basel, Switzerland)2019
Isonitrile-Derivatized Indole as an Infrared Probe for Hydrogen-Bonding Environments.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Synthesis and Characterization of 4-Indolylcyanamide: A Potential IR Probe for Local Environment.Molecules (Basel, Switzerland) · 2025Article
- Investigation of the Vibrational Characteristics of 6-Isocyano-1-Methyl-1H-Indole: Utilizing the Isonitrile Group as an Infrared Probe.Molecules (Basel, Switzerland) · 2023Article
- Dual Photochemistry of Benzimidazole.The Journal of organic chemistry · 2023Article
- The Global Polarity of Alcoholic Solvents and Water - Importance of the Collectively Acting Factors Density, Refractive Index and Hydrogen Bonding Forces.ChemistryOpen · 2022Article
- Transparent window 2D IR spectroscopy of proteins.The Journal of chemical physics · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The isonitrile (NC) group has been shown to be a promising infrared probe for studying the structure and dynamics of biomolecules. However, there have been no systematic studies performed on the NC group as an infrared probe, when it is bonded to an indole ring. Here, we systematically study the NC stretching mode of two model compounds, 5-isocyano-1H-indole (5ICI) and 5-isocyano-1-methyl-1H-indole (NM5ICI), using Fourier transform infrared (FTIR) spectroscopy. The NC stretching frequency is shown to be strongly dependent on the polarizability of protic solvents and the density of hydrogen-bond donor groups in the solvent when NC is bonded to an indole ring. Infrared pump⁻probe studies of 5ICI in DMSO and in EtOH further support that the NC stretching mode could be used as a site-specific infrared probe for local environments when NC is bonded to an indole ring.
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