Evidence map›Paper›PMID 30965624›Full record

ArticleBiomedicines2019

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Re-Growth in Androgenetic Alopecia. Biomolecular Pathway Analysis and Clinical Evaluation.

Pietro Gentile, Maria G Scioli, Alessandra Bielli, Barbara De Angelis, Ciro De Sio, Domenico De Fazio, Gabriele Ceccarelli, Angelo Trivisonno, Augusto Orlandi, Valerio Cervelli and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 6 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 6 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
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  3. The use of platelet-rich plasma in wound healing and vitiligo: A systematic review and meta-analysis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
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  7. Evaluation of the effects of adding an adipose tissue-derived stromal vascular fraction to platelet-rich plasma injection in the treatment of androgenetic alopecia: A randomized clinical trial.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Pietro GentileDepartment of Surgical Sciences, Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", 00173 Rome, Italy. pietrogentile2004@libero.it.
Maria G ScioliDepartment of Biomedicine and Prevention, Institute of Anatomic Pathology, University of Rome "Tor Vergata", 00173 Rome, Italy. scioli@med.uniroma2.it.
Alessandra BielliDepartment of Biomedicine and Prevention, Institute of Anatomic Pathology, University of Rome "Tor Vergata", 00173 Rome, Italy. alessandrabielli@hotmail.it.
Barbara De AngelisDepartment of Surgical Sciences, Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", 00173 Rome, Italy. bdeangelisdoc@gmail.com.
Ciro De SioPrivate Plastic Surgeon, 00168 Rome, Italy. dr.cdesio@gmail.com.
Domenico De FazioPrivate Plastic Surgeon, 00168 Rome, Italy. defazioplastic@gmail.com.
Gabriele CeccarelliDepartment of Public Health, Experimental Medicine and Forensic, Human Anatomy Unit, University of Pavia, 27100 Pavia, Italy. gabriele.ceccarelli@unipv.it.
Angelo TrivisonnoPrivate Plastic Surgeon, 00168 Rome, Italy. dott.a.trivisonno@gmail.com.
Augusto OrlandiDepartment of Biomedicine and Prevention, Institute of Anatomic Pathology, University of Rome "Tor Vergata", 00173 Rome, Italy. orlandi@uniroma2.it.
Valerio CervelliDepartment of Surgical Sciences, Plastic and Reconstructive Surgery, University of Rome "Tor Vergata", 00173 Rome, Italy. valeriocervelli@virgilio.it.
Simone GarcovichInstitute of Dermatology, F. Policlinico Gemelli, IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. simgarko@yahoo.it.
University of Rome Tor Vergata · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet rich plasma (PRP) and Micrografts containing human follicle mesenchymal stem cells (HF-MSCs) were tried as a potential treatment for androgenetic alopecia (AGA). However, little to no work has yet to be seen wherein the bio-molecular pathway of HF-MSCs or PRP treatments were analyzed. The aims of this work are to report the clinical effectiveness of HF-MSCs and platelet-rich plasma evaluating and reviewing the most updated information related to the bio-molecular pathway. Twenty-one patients were treated with HF-MSCs injections and 57 patients were treated with A-PRP. The Wnt pathway and Platelet derived-growth factors effects were analyzed. 23 weeks after the last treatment with mean hair thickness increments (29 ± 5.0%) over baseline values for the targeted area. 12 weeks after the last injection with A-PRP mean hair count and hair density (31 ± 2%) increases significantly over baseline values. The increment of Wnt signaling in Dermal Papilla Cells evidently is one of the principal factors that enhances hair growth. Signaling from mesenchymal stem cells and platelet derived growth factors positively influences hair growth through cellular proliferation to prolong the anagen phase (FGF-7), inducing cell growth (ERK activation), stimulating hair follicle development (β-catenin), and suppressing apoptotic cues (Bcl-2 release and Akt activation).

Indexed as

hair losshair-regrowthHF-MSCshuman follicle mesenchymal stem cellsmicrograftsplatelet rich plasmaPRPPRP hairstem cells hair

Identifiers

PMID30965624
PMCPMC6631937
OpenAlexW2938349404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.