Evidence map›Paper›PMID 30965340›Full record

ArticleNeonatology2019

Lack of Evidence for Time or Dose Relationship between Antenatal Magnesium Sulfate and Intestinal Injury in Extremely Preterm Neonates.

Michel Mikhael, Cheryl Bronson, Lishi Zhang, Mark Curran, Helen Rodriguez, Kushal Y Bhakta

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neonatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants-a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Pooled it
  2. Pooled it
  3. Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22-24 weeks' gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Observational
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Michel MikhaelDivision of Neonatology, Pomona Valley Hospital Medical Center, Pomona, California, USA, mmikhael@choc.org.
Cheryl BronsonDivision of Neonatology, Pomona Valley Hospital Medical Center, Pomona, California, USA.
Lishi ZhangInstitute for Clinical and Translational Science, University of California, Irvine, California, USA.
Mark CurranDivision of Maternal Fetal Medicine, Pomona Valley Hospital Medical Center, Pomona, California, USA.
Helen RodriguezDivision of Maternal Fetal Medicine, Pomona Valley Hospital Medical Center, Pomona, California, USA.
Kushal Y BhaktaDivision of Neonatology, Pomona Valley Hospital Medical Center, Pomona, California, USA.
Pomona Valley Hospital Medical Center · USChildren's Hospital of Orange County · USUniversity of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

backgroundRecent studies reported conflicting results on the relationship between antenatal magnesium sulfate (MgSO4) exposure and neonatal intestinal injury. Most studies have not assessed MgSO4 exposure quantitatively and none reported the exposure timing.

objectivesThe aim of this work was to assess whether there is a temporal or dose-dependent relationship between antenatal MgSO4 exposure and intestinal injury in extremely preterm neonates.

methodsA retrospective study was made of inborn neonates with gestational age ≤28 weeks and/or birth weights ≤1,000 g. Primary outcomes included necrotizing enterocolitis (NEC), spontaneous intestinal perforation (SIP), and/or death prior to discharge or in the first 2 weeks of life. Outcome comparisons were made based on the timing of MgSO4 exposure, within 7 days (Mg7D) or within 3 days (Mg3D) of birth. Total cumulative doses for the Mg3D group were also computed.

resultsA total of 302 neonates were included, 210 in the Mg7D group, out of whom 179 (85.2%) constituted the Mg3D group. There were no differences noted when comparing MgSO4 exposure timing and the likelihood of NEC, SIP, and/or death. This remained the same for subgroup analysis of neonates < 26 weeks' gestation. Each 10-g increase in MgSO4 cumulative dose correlated with a decrease in SIP/NEC/death by 18.9% prior to discharge and by 21.9% in the first 2 weeks of life. Small for gestational age (SGA) was a potential effect modifier by a likelihood ratio test with p = 0.07.

conclusionsAntenatal MgSO4 exposure in extremely preterm neonates was not associated with an increased risk of intestinal injury or death, and might have reduced these complications in a dose-dependent manner in our study. This protective effect was more noticeable in SGA neonates.

Indexed as

Infant, Extremely PrematureCaliforniaDose-Response Relationship, DrugFemaleGestational AgeHumansInfant, NewbornInfant, Premature, DiseasesInfant, Small for Gestational AgeIntestinal PerforationLogistic ModelsMagnesium SulfateMaleMultivariate AnalysisPregnancyPrenatal Exposure Delayed EffectsMagnesium SulfateMagnesium sulfateNecrotizing enterocolitisSpontaneous intestinal perforation

Identifiers

PMID30965340
PMCPMC6554036
OpenAlexW2935960670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.