Evidence map›Paper›PMID 30965152›Full record

ArticleBiomaterials2019

Engineering a naturally-derived adhesive and conductive cardiopatch.

Brian W Walker, Roberto Portillo Lara, Chu Hsiang Yu, Ehsan Shirzaei Sani, William Kimball, Shannon Joyce, Nasim Annabi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  10. Gelated microvesicle-mediated delivery of mesenchymal stem cell mitochondria for the treatment of myocardial infarction.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brian W WalkerDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA 90095, USA.
Roberto Portillo LaraDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Zapopan, JAL, Mexico.
Chu Hsiang YuDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Ehsan Shirzaei SaniDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA 90095, USA.
William KimballDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Shannon JoyceDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA 90095, USA; Biomaterials Innovation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute (CNSI), University of California - Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: nannabi@ucla.edu.

Funding

Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
NHLBI NIH HHS R01 HL140618NIBIB NIH HHS R01 EB023052
6 · The paper itself

Abstract

Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered cardiac tissues in vitro, there are still several limitations associated with engineering biocompatible scaffolds with appropriate mechanical properties and electroconductivity for cardiac tissue regeneration. Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. These GelMA/Bio-IL adhesive patches were optimized to exhibit mechanical and conductive properties similar to the native myocardium. Furthermore, the engineered patches strongly adhered to murine myocardium due to the formation of ionic bonding between the Bio-IL and native tissue, eliminating the need for suturing. Co-cultures of primary cardiomyocytes and cardiac fibroblasts grown on GelMA/Bio-IL patches exhibited comparatively better contractile profiles compared to pristine GelMA controls, as demonstrated by over-expression of the gap junction protein connexin 43. These cardiopatches could be used to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function.

Indexed as

AnimalsElectric ConductivityFemaleGelatinMyocardial InfarctionMyocardiumRats, WistarTissue EngineeringTissue ScaffoldsGelatinBio-ionic liquidCardiac patchCardiac tissue engineeringElectrospinningGelMA

Identifiers

PMID30965152
PMCPMC6470010

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.