Evidence map›Paper›PMID 30965084›Full record

ArticlePeptides2019

Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice.

Ramu Periyasamy, Subhankar Das, Kailash N Pandey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Peptides, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Renal Tubule Cell-SpecificHypertension (Dallas, Tex. : 1979) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Depletion of cyclic-GMP levels and inhibition of cGMP-dependent protein kinase activate p21FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ramu PeriyasamyDepartment of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA, 70112, United States.
Subhankar DasDepartment of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA, 70112, United States.
Kailash N PandeyDepartment of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA, 70112, United States. Electronic address: kpandey@tulane.edu.

Funding

Study of ANP Receptor:Gene Targeting and ExpressionR01HL062147 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1998 to 2020
$5.0M
ANP RECEPTOR--MOLECULAR APPROACH OF SIGNALING MECHANISMSR01HL057531 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1997 to 2013
$2.5M
ANP Receptor: Molecular approach of signaling mechanismsR56HL057531 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 2009 to 2009
$373k
NHLBI NIH HHS R01 HL057531NHLBI NIH HHS R01 HL062147NHLBI NIH HHS R56 HL057531
6 · The paper itself

Abstract

The objective of the present study was to determine whether targeted-disruption of Npr1 gene (encoding for guanylyl cyclase/natriuretic peptide receptor-A; GC-A/NPRA) upregulates pro(renin) receptor (P)RR expression and leads to the activation of MAPKs in Npr1 gene-knockout mice. The Npr1 homozygous (Npr1

Indexed as

Angiotensin IIAnimalsAntihypertensive AgentsBlood PressureCaptoprilCyclic GMPFemaleKidneyLosartanMaleMice, Inbred C57BLMice, KnockoutMice, Mutant StrainsMitogen-Activated Protein KinasesPeptidyl-Dipeptidase AProrenin ReceptorAngiotensin IIAntihypertensive Agentsatrial natriuretic factor receptor ACaptoprilCyclic GMPLosartanMitogen-Activated Protein KinasesPeptidyl-Dipeptidase AProrenin ReceptorReceptor, Angiotensin, Type 1Receptors, Atrial Natriuretic FactorReceptors, Cell SurfaceAtrial natriuretic peptide receptorMitogen-activated protein kinasesProinflammatory cytokines(Pro) renin receptorRenin angiotensin system

Identifiers

PMID30965084
PMCPMC6821518

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.