Evidence map›Paper›PMID 30964994›Full record

ArticleThe journal of physical chemistry. B2019

Exact Solutions for Distributions of First-Passage, Direct-Transit, and Looping Times in Symmetric Cusp Potential Barriers and Wells.

Alexander M Berezhkovskii, Leonardo Dagdug, Sergey M Bezrukov

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. Broad distributions of transition-path times are fingerprints of multidimensionality of the underlying free energy landscapes.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Alexander M BerezhkovskiiSection on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health , Bethesda , Maryland 20892 , United States.
Leonardo DagdugDepartamento de Fisica , Universidad Autonoma Metropolitana-Iztapalapa , 09340 Mexico City , Mexico.
Sergey M BezrukovSection on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health , Bethesda , Maryland 20892 , United States.ORCID 0000-0002-8209-8050
National Institutes of Health · USUniversidad Autónoma Metropolitana · MX

Funding

Modeling of kinetic processes in biological systemsZIACT000273 · CIT · CENTER FOR INFORMATION TECHNOLOGY · PI BEREZHKOVSKII, ALEXANDER · 2009 to 2021
$2.1M
Intramural NIH HHS ZIA CT000273
6 · The paper itself

Abstract

For a particle diffusing in one dimension, the distribution of its first-passage time from point a to point b is determined by the durations of the particle trajectories that start from point a and are terminated as soon as they touch point b for the first time. Any such trajectory consists of looping and direct-transit segments. The latter is the final part of the trajectory that leaves point a and goes to point b without returning to point a. The rest of the trajectory is the looping segment that makes numerous loops which begin and end at the same point a without touching point b. In this article we discuss general relations between the first-passage time distribution and those for the durations of the two segments. These general relations allow us to find exact solutions for the Laplace transforms of the distributions of the first-passage, direct-transit, and looping times for transitions between two points separated by a symmetric cusp potential barrier or well of arbitrary height and depth, respectively. The obtained Laplace transforms are inverted numerically, leading to nontrivial dependences of the resulting distributions on the barrier height and the well depth.

Indexed as

AlgorithmsDiffusionHumansMitochondrial MembranesMolecular Dynamics SimulationParticle SizeSolutionsSurface PropertiesSolutions

Identifiers

PMID30964994
PMCPMC6749835
OpenAlexW2938633298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.