Evidence map›Paper›PMID 30964711›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

MCPH1 is essential for cellular adaptation to the G

María Arroyo, Ryoko Kuriyama, Israel Guerrero, Daniel Keifenheim, Ana Cañuelo, Jesús Calahorra, Antonio Sánchez, Duncan J Clarke, J Alberto Marchal

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

María ArroyoDepartamento de Biología Experimental, Universidad de Jaén, Jaén, Spain.
Ryoko KuriyamaDepartment of Genetics, Cell Biology, and Development, University of Minnesota-Minneapolis, Minneapolis, Minnesota, USA.
Israel GuerreroInstituto de Investigación y Formación Agraria y Pesquera (IFAPA Centro El Toruño), El Puerto de Santa María, Spain.
Daniel KeifenheimDepartment of Genetics, Cell Biology, and Development, University of Minnesota-Minneapolis, Minneapolis, Minnesota, USA.
Ana CañueloDepartamento de Biología Experimental, Universidad de Jaén, Jaén, Spain.
Jesús CalahorraDepartamento de Biología Experimental, Universidad de Jaén, Jaén, Spain.
Antonio SánchezDepartamento de Biología Experimental, Universidad de Jaén, Jaén, Spain.
Duncan J ClarkeDepartment of Genetics, Cell Biology, and Development, University of Minnesota-Minneapolis, Minneapolis, Minnesota, USA.
J Alberto MarchalDepartamento de Biología Experimental, Universidad de Jaén, Jaén, Spain.
Universidad de Jaén · ESUniversity of Minnesota · USAndalusian Institute of Agricultural and Fisheries Research and Training · ES

Funding

Control of Chromosome Segregation by DNA Topoisomerase IIR01GM130858 · NIGMS · UNIVERSITY OF MINNESOTA · PI DUNCAN J. CLARKE · 2019 to 2026
$2.2M
Regulation of kinetochore function by Topoisomerase IIR01GM112793 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI AZUMA, YOSHIAKI, CLARKE, DUNCAN J. · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM112793NIGMS NIH HHS R01 GM130858
6 · The paper itself

Abstract

Cellular checkpoints controlling entry into mitosis monitor the integrity of the DNA and delay mitosis onset until the alteration is fully repaired. However, this canonical response can weaken, leading to a spontaneous bypass of the checkpoint, a process referred to as checkpoint adaptation. Here, we have investigated the contribution of microcephalin 1 (MCPH1), mutated in primary microcephaly, to the decatenation checkpoint, a less-understood G

Indexed as

G2 Phase Cell Cycle CheckpointsAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell Line, TransformedCytoskeletal ProteinsHumansAtaxia Telangiectasia Mutated ProteinsATM protein, humanCell Cycle ProteinsCytoskeletal ProteinsMCPH1 protein, humancell cycle controlcheckpoint adaptationchromosome condensationMCPH1topoisomerase II

Identifiers

PMID30964711
PMCPMC6593890
OpenAlexW2939470646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.