Evidence map›Paper›PMID 30964661›Full record

ArticleJournal of medicinal chemistry2019

D

Yudao Shen, John D McCorvy, Michael L Martini, Ramona M Rodriguiz, Vladimir M Pogorelov, Karen M Ward, William C Wetsel, Jing Liu, Bryan L Roth, Jian Jin

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Potent and Subtype-Selective Dopamine DJournal of medicinal chemistry · 2021
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yudao ShenMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
John D McCorvyDepartment of Pharmacology and National Institute of Mental Health Psychoactive Drug Screening Program, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.
Michael L MartiniMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Ramona M RodriguizDepartments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurobiology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Vladimir M PogorelovDepartments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurobiology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Karen M WardWorldwide Research and Development , Internal Medicine Research Unit, Pfizer , Cambridge , Massachusetts 02139 , United States.
William C WetselDepartments of Psychiatry and Behavioral Sciences, Cell Biology, and Neurobiology , Duke University Medical Center , Durham , North Carolina 27710 , United States.
Jing LiuMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.
Bryan L RothDepartment of Pharmacology and National Institute of Mental Health Psychoactive Drug Screening Program, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.ORCID 0000-0002-0561-6520
Jian JinMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.ORCID 0000-0002-2387-3862
Icahn School of Medicine at Mount Sinai · USDuke University · USUniversity of North Carolina at Chapel Hill · USPfizer (United States) · US

Funding

MOUNT SINAI MEDICAL SCIENTIST TRAINING PROGRAMT32GM007280 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H · 1985 to 2021
$22.8M
Screening CoreU19MH082441 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARON, MARC G., ROTH, BRYAN L. · 2007 to 2016
$15.2M
Illuminating the Druggable GPCR-omeU24DK116195 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTH, BRYAN L., SHOICHET, BRIAN K · 2017 to 2022
$14.3M
Teaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2M
Molecular Details of Psychoactive Drug ActionsR01MH112205 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth, Brian K Shoichet · 2017 to 2026
$6.1M
Exploiting Dopamine Receptor Functional Selectivity as an Approach to Treat Parkinson's SymptomsR01NS100930 · NINDS · DUKE UNIVERSITY · PI CARON, MARC G. · 2017 to 2021
$3.2M
NIDDK NIH HHS U24 DK116195NIGMS NIH HHS T32 GM007280NIGMS NIH HHS T32 GM062754NIMH NIH HHS R01 MH112205NIMH NIH HHS U19 MH082441NINDS NIH HHS R01 NS100930
6 · The paper itself

Abstract

Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the roles of downstream signaling pathways that potentially contribute to therapeutic effects versus side effects. Recently, we discovered both G

Indexed as

AnimalsAntipsychotic Agentsbeta-Arrestin 2Dopamine AgonistsDrug DesignDrug Partial AgonismFemaleGTP-Binding Protein alpha Subunits, Gi-GoHEK293 CellsHumansIsoquinolinesLocomotionMaleMethylurea CompoundsMice, Inbred C57BLMolecular Docking SimulationAntipsychotic Agentsbeta-Arrestin 2cariprazineDopamine AgonistsGTP-Binding Protein alpha Subunits, Gi-GoIsoquinolinesMethylurea CompoundsPiperazinesReceptors, Dopamine D2

Identifiers

PMID30964661
PMCPMC6509010
OpenAlexW2937911595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.